TCGA mRNA Expression Analysis of the Heme Biosynthesis Pathway in Diffusely Infiltrating Gliomas: A Comparison of Typically 5-ALA Fluorescent and Non-Fluorescent Gliomas

TCGA mRNA Expression Analysis of the Heme Biosynthesis Pathway in Diffusely Infiltrating Gliomas: A Comparison of Typically 5-ALA Fluorescent and Non-Fluorescent Gliomas

5-Aminolevulinic acid (5-ALA) is a fluorescent dye that after metabolization to Protoporphyrin IX (PpIX) by the heme biosynthesis pathway typically leads to visible fluorescence in WHO grade IV but not grade II gliomas. The exact mechanism for high PpIX levels in WHO grade IV gliomas and low PpIX le...

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Bibliographic Details
Main Authors: Mario Mischkulnig, Barbara Kiesel, Daniela Lötsch, Thomas Roetzer, Martin Borkovec, Lisa I. Wadiura, Petra A. Mercea, Florian J. Jaklin, Shawn Hervey-Jumper, Karl Roessler, Mitchel S. Berger, Georg Widhalm, Friedrich Erhart
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
5-ALA
fluorescence
glioma
heme biosynthesis
TCGA
gene expression
Online Access:https://www.mdpi.com/2072-6694/12/8/2043

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