The Effects of Early Nutritional Intervention on Oral Mucositis and Nutritional Status of Patients With Head and Neck Cancer Treated With Radiotherapy
Radiation-induced oral mucositis (RIOM) is a common side effect after radiotherapy (RT) in head and neck cancer (HNC) patients. RIOM patients with severe pain have difficulty in eating, which increases the incidence of malnutrition and affects patients’ quality of life and the process of RT. The mec...
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Frontiers Media S.A.
2021-02-01
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Series: | Frontiers in Oncology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.595632/full |
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doaj-64b70bad16da4ae49a57025aa73da07f |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhuangzhuang Zheng Zhuangzhuang Zheng Zhuangzhuang Zheng Xin Zhao Qin Zhao Qin Zhao Qin Zhao Yuyu Zhang Yuyu Zhang Yuyu Zhang Shiyu Liu Shiyu Liu Shiyu Liu Zijing Liu Zijing Liu Zijing Liu Lingbin Meng Ying Xin Xin Jiang Xin Jiang Xin Jiang |
spellingShingle |
Zhuangzhuang Zheng Zhuangzhuang Zheng Zhuangzhuang Zheng Xin Zhao Qin Zhao Qin Zhao Qin Zhao Yuyu Zhang Yuyu Zhang Yuyu Zhang Shiyu Liu Shiyu Liu Shiyu Liu Zijing Liu Zijing Liu Zijing Liu Lingbin Meng Ying Xin Xin Jiang Xin Jiang Xin Jiang The Effects of Early Nutritional Intervention on Oral Mucositis and Nutritional Status of Patients With Head and Neck Cancer Treated With Radiotherapy Frontiers in Oncology early nutritional intervention head and neck cancer radiotherapy oral mucositis malnutrition |
author_facet |
Zhuangzhuang Zheng Zhuangzhuang Zheng Zhuangzhuang Zheng Xin Zhao Qin Zhao Qin Zhao Qin Zhao Yuyu Zhang Yuyu Zhang Yuyu Zhang Shiyu Liu Shiyu Liu Shiyu Liu Zijing Liu Zijing Liu Zijing Liu Lingbin Meng Ying Xin Xin Jiang Xin Jiang Xin Jiang |
author_sort |
Zhuangzhuang Zheng |
title |
The Effects of Early Nutritional Intervention on Oral Mucositis and Nutritional Status of Patients With Head and Neck Cancer Treated With Radiotherapy |
title_short |
The Effects of Early Nutritional Intervention on Oral Mucositis and Nutritional Status of Patients With Head and Neck Cancer Treated With Radiotherapy |
title_full |
The Effects of Early Nutritional Intervention on Oral Mucositis and Nutritional Status of Patients With Head and Neck Cancer Treated With Radiotherapy |
title_fullStr |
The Effects of Early Nutritional Intervention on Oral Mucositis and Nutritional Status of Patients With Head and Neck Cancer Treated With Radiotherapy |
title_full_unstemmed |
The Effects of Early Nutritional Intervention on Oral Mucositis and Nutritional Status of Patients With Head and Neck Cancer Treated With Radiotherapy |
title_sort |
effects of early nutritional intervention on oral mucositis and nutritional status of patients with head and neck cancer treated with radiotherapy |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-02-01 |
description |
Radiation-induced oral mucositis (RIOM) is a common side effect after radiotherapy (RT) in head and neck cancer (HNC) patients. RIOM patients with severe pain have difficulty in eating, which increases the incidence of malnutrition and affects patients’ quality of life and the process of RT. The mechanism of RIOM is not fully understood, and inflammatory response and oxidative stress appear to be important for RIOM occurrence and development. The nutritional status of patients is very important for their RT tolerance and recovery. Malnutrition, which can lead to anemia, low protein, decreased immunity and other problems, is an important clinical factor affecting tumor progression and treatment. Recent studies have shown that early nutritional intervention can ameliorate oral mucositis and nutritional status of patients with HNC. However, in clinical practice, early nutritional intervention for patients with HNC is not a conventional intervention strategy. Therefore, this review summarized the possible pathogenesis of RIOM, commonly used assessment tools for malnutrition in patients, and recent studies on the effects of early nutritional interventions on RIOM and nutritional status of patients with HNC. We hope to provide the basis and reference for the clinical application of early nutritional intervention models. |
topic |
early nutritional intervention head and neck cancer radiotherapy oral mucositis malnutrition |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2020.595632/full |
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doaj-64b70bad16da4ae49a57025aa73da07f2021-02-01T05:50:46ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-02-011010.3389/fonc.2020.595632595632The Effects of Early Nutritional Intervention on Oral Mucositis and Nutritional Status of Patients With Head and Neck Cancer Treated With RadiotherapyZhuangzhuang Zheng0Zhuangzhuang Zheng1Zhuangzhuang Zheng2Xin Zhao3Qin Zhao4Qin Zhao5Qin Zhao6Yuyu Zhang7Yuyu Zhang8Yuyu Zhang9Shiyu Liu10Shiyu Liu11Shiyu Liu12Zijing Liu13Zijing Liu14Zijing Liu15Lingbin Meng16Ying Xin17Xin Jiang18Xin Jiang19Xin Jiang20Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, ChinaJilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun, ChinaNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, ChinaDepartment of Orthopedic, The Second Hospital of Jilin University, Changchun, ChinaDepartment of Radiation Oncology, The First Hospital of Jilin University, Changchun, ChinaJilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun, ChinaNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, ChinaDepartment of Radiation Oncology, The First Hospital of Jilin University, Changchun, ChinaJilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun, ChinaNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, ChinaDepartment of Radiation Oncology, The First Hospital of Jilin University, Changchun, ChinaJilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun, ChinaNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, ChinaDepartment of Radiation Oncology, The First Hospital of Jilin University, Changchun, ChinaJilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun, ChinaNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, ChinaDepartment of Hematology and Medical Oncology, Moffitt Cancer Center, Tampa, FL, United StatesKey Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, ChinaDepartment of Radiation Oncology, The First Hospital of Jilin University, Changchun, ChinaJilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun, ChinaNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, ChinaRadiation-induced oral mucositis (RIOM) is a common side effect after radiotherapy (RT) in head and neck cancer (HNC) patients. RIOM patients with severe pain have difficulty in eating, which increases the incidence of malnutrition and affects patients’ quality of life and the process of RT. The mechanism of RIOM is not fully understood, and inflammatory response and oxidative stress appear to be important for RIOM occurrence and development. The nutritional status of patients is very important for their RT tolerance and recovery. Malnutrition, which can lead to anemia, low protein, decreased immunity and other problems, is an important clinical factor affecting tumor progression and treatment. Recent studies have shown that early nutritional intervention can ameliorate oral mucositis and nutritional status of patients with HNC. However, in clinical practice, early nutritional intervention for patients with HNC is not a conventional intervention strategy. Therefore, this review summarized the possible pathogenesis of RIOM, commonly used assessment tools for malnutrition in patients, and recent studies on the effects of early nutritional interventions on RIOM and nutritional status of patients with HNC. We hope to provide the basis and reference for the clinical application of early nutritional intervention models.https://www.frontiersin.org/articles/10.3389/fonc.2020.595632/fullearly nutritional interventionhead and neck cancerradiotherapyoral mucositismalnutrition |