The Role of Liquid Biopsies in Detecting Molecular Tumor Biomarkers in Brain Cancer Patients

The Role of Liquid Biopsies in Detecting Molecular Tumor Biomarkers in Brain Cancer Patients

Glioblastoma multiforme (GBM) is one of the most lethal primary central nervous system cancers with a median overall survival of only 12–15 months. The best documented treatment is surgical tumor debulking followed by chemoradiation and adjuvant chemotherapy with temozolomide, but treatment resistan...

Full description

Bibliographic Details
Main Authors:	Heena Sareen, Celine Garrett, David Lynch, Branka Powter, Daniel Brungs, Adam Cooper, Joseph Po, Eng-Siew Koh, Joey Yusof Vessey, Simon McKechnie, Renata Bazina, Mark Sheridan, James van Gelder, Balsam Darwish, Mathias Jaeger, Tara L. Roberts, Paul De Souza, Therese M. Becker
Format:	Article
Language:	English
Published:	MDPI AG 2020-07-01
Series:	Cancers
Subjects:	glioma biomarker IDHI MGMT EGFR
Online Access:	https://www.mdpi.com/2072-6694/12/7/1831

Similar Items

The prognostic role of IDH mutations in homogeneously treated patients with anaplastic astrocytomas and glioblastomas
by: Arne Christians, et al.
Published: (2019-10-01)

Correlation of MGMT promoter methylation status with gene and protein expression levels in glioblastoma
by: Miyuki Uno, et al.
Published: (2011-01-01)

Clinical insights gained by refining the 2016 WHO classification of diffuse gliomas with: EGFR amplification, TERT mutations, PTEN deletion and MGMT methylation
by: Cheila Brito, et al.
Published: (2019-10-01)

Isolation of Circulating Tumor Cells from Glioblastoma Patients by Direct Immunomagnetic Targeting
by: David Lynch, et al.
Published: (2020-05-01)

Veränderungen im MGMT-Status von humanen Glioblastomzelllinien
by: Müller-Ritz, Johanna
Published: (2018)

Prognostic genetic markers in malignant gliomas
by: Ralf Ketter, et al.
Published: (2010-12-01)

The significance of MGMT protein detection in evaluation of osteosarcoma necrosis rate after cisplatin chemotherapy
by: Qiu Cui, et al.
Published: (2011-05-01)

O<sup>6</sup>-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis
by: Altamura Gennaro, et al.
Published: (2012-11-01)

Lomeguatrib Increases the Radiosensitivity of MGMT Unmethylated Human Glioblastoma Multiforme Cell Lines
by: Anna Kirstein, et al.
Published: (2021-06-01)

Topographical Mapping of 436 Newly Diagnosed IDH Wildtype Glioblastoma With vs. Without MGMT Promoter Methylation
by: Fatih Incekara, et al.
Published: (2020-05-01)

Prognostic Significance of MGMT Promoter Methylation in Patients with Glioblastoma Undergoing Surgical Intervention: A Retrospective Study in Northeastern Iran
by: Kazem Anvari, et al.
Published: (2018-07-01)

Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: One step forward, and one step back?
by: Combs Stephanie E, et al.
Published: (2011-09-01)

Temozolomide Induced Hypermutation in Glioma: Evolutionary Mechanisms and Therapeutic Opportunities
by: Paul Daniel, et al.
Published: (2019-02-01)

Efficacy of Whole-Ventricular Radiotherapy in Patients Undergoing Maximal Tumor Resection for Glioblastomas Involving the Ventricle
by: Kyung Hwan Kim, et al.
Published: (2021-09-01)

Retrospective and Randomized Analysis of Influence and Correlation of Clinical and Molecular Prognostic Factors in a Mono-Operative Series of 122 Patients with Glioblastoma Treated with STR or GTR
by: Maurizio Salvati, et al.
Published: (2020-02-01)

Does age really matter? Radiotherapy in elderly patients with glioblastoma, the Munich experience
by: Christoph Straube, et al.
Published: (2017-04-01)

Assessing Versatile Machine Learning Models for Glioma Radiogenomic Studies across Hospitals
by: Risa K. Kawaguchi, et al.
Published: (2021-07-01)

Treatment options and outcomes for glioblastoma in the elderly patient
by: Arvold ND, et al.
Published: (2014-02-01)

Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins
by: Gaspar J. Kitange, et al.
Published: (2016-03-01)

MGMT autoantibodies as a potential prediction of recurrence and treatment response biomarker for glioma patients
by: Haibin Wu, et al.
Published: (2019-08-01)

An intronic genetic variation of MGMT affects enhancer activity and is associated with glioma susceptibility
by: Huang L, et al.
Published: (2018-09-01)

Potential Role of Methylation Marker in Glioma Supporting Clinical Decisions
by: Krzysztof Roszkowski, et al.
Published: (2016-11-01)

A Novel DNA Methylation-Based Signature Can Predict the Responses of MGMT Promoter Unmethylated Glioblastomas to Temozolomide
by: Rui-Chao Chai, et al.
Published: (2019-09-01)

Looking for A Place for Dose-Dense TMZ Regimens in GBM Patients: An Experience with MGMT Exploratory Evaluation
by: Luca Napoleoni, et al.
Published: (2019-01-01)

Glioblastoma management: challenges in the elderly population
by: Niranjan Tachamo, et al.
Published: (2016-10-01)

Association Between MGMT Promoter Methylation and Breast Cancer: a Meta-Analysis
by: Nairui An, et al.
Published: (2017-08-01)

CAT3, a prodrug of 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine, circumvents temozolomide-resistant glioblastoma via the Hedgehog signaling pathway, independently of O6-methylguanine DNA methyltransferase expression
by: Ji M, et al.
Published: (2018-06-01)

Glioblastoma and the significance of MGMT gene methylation
by: Payam Izadpanahi, et al.
Published: (2014-08-01)

A long non-coding RNA signature in glioblastoma multiforme predicts survival
by: Xiao-Qin Zhang, et al.
Published: (2013-10-01)

MGMT methylation alterations in brain cancer following organochlorine pesticides exposure
by: Fatemeh Yousefi, et al.
Published: (2021-02-01)

MIND MGMT: Paranoid Nightmares of a Fugitive Reality.
by: Pepe Rojo
Published: (2017-06-01)

Influence of Intratumor Heterogeneity on the Predictivity of MGMT Gene Promoter Methylation Status in Glioblastoma
by: Giovanni Brigliadori, et al.
Published: (2020-10-01)

The distribution of isocitrate dehydrogenase mutations, O6-methylguanine-DNA methyltransferase promoter methylation, and 1p/19q codeletion in different glioma subtypes and their correlation with glioma prognosis in Taiwanese population: A single center study
by: Peng-Wei Hsu, et al.
Published: (2021-03-01)

The interaction between TERT promoter mutation and MGMT promoter methylation on overall survival of glioma patients: a meta-analysis
by: Huy Gia Vuong, et al.
Published: (2020-09-01)

The Role of miRNA for the Treatment of MGMT Unmethylated Glioblastoma Multiforme
by: Anna Kirstein, et al.
Published: (2020-04-01)

O6-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy
by: Wei Yu, et al.
Published: (2020-01-01)

Levetiracetam enhances the temozolomide effect on glioblastoma stem cell proliferation and apoptosis
by: Bianca Maria Scicchitano, et al.
Published: (2018-09-01)

Mifepristone Overcomes Tumor Resistance to Temozolomide Associated with DNA Damage Repair and Apoptosis in an Orthotopic Model of Glioblastoma
by: Monserrat Llaguno-Munive, et al.
Published: (2018-12-01)

Temozolomide in aggressive pituitary adenomas and carcinomas
by: Leon D. Ortiz, et al.
Published: (2012-01-01)

Rare Stochastic Expression of O6-Methylguanine- DNA Methyltransferase (MGMT) in MGMT-Negative Melanoma Cells Determines Immediate Emergence of Drug-Resistant Populations upon Treatment with Temozolomide In Vitro and In Vivo
by: Thomas C. Chen, et al.
Published: (2018-09-01)