Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1)
Regulator of Chromatin Condensation 1 (RCC1) is the only known guanine nucleotide exchange factor that acts on the Ras-like G protein Ran and plays a key role in cell cycle regulation. Although there is growing evidence to support the relationship between RCC1 and cancer, detailed pancancer analyses...
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doaj-64cfea10aac0474e829d3c96a001c8022021-07-23T13:45:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-01227374737410.3390/ijms22147374Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1)Changwu Wu0Yingjuan Duan1Siming Gong2Sonja Kallendrusch3Nikolas Schopow4Georg Osterhoff5Institute of Anatomy, University of Leipzig, Liebigstraße 13, 04103 Leipzig, GermanyFaculty of Chemistry and Mineralogy, University of Leipzig, 04103 Leipzig, GermanyInstitute of Anatomy, University of Leipzig, Liebigstraße 13, 04103 Leipzig, GermanyInstitute of Anatomy, University of Leipzig, Liebigstraße 13, 04103 Leipzig, GermanyInstitute of Anatomy, University of Leipzig, Liebigstraße 13, 04103 Leipzig, GermanySarcoma Center, Department of Orthopedics, Trauma and Plastic Surgery, University Hospital Leipzig, 04103 Leipzig, GermanyRegulator of Chromatin Condensation 1 (RCC1) is the only known guanine nucleotide exchange factor that acts on the Ras-like G protein Ran and plays a key role in cell cycle regulation. Although there is growing evidence to support the relationship between RCC1 and cancer, detailed pancancer analyses have not yet been performed. In this genome database study, based on The Cancer Genome Atlas, Genotype-Tissue Expression and Gene Expression Omnibus databases, the potential role of RCC1 in 33 tumors’ entities was explored. The results show that RCC1 is highly expressed in most human malignant neoplasms in contrast to healthy tissues. RCC1 expression is closely related to the prognosis of a broad variety of tumor patients. Enrichment analysis showed that some tumor-related pathways such as “cell cycle” and “RNA transport” were involved in the functional mechanism of RCC1. In particular, the conducted analysis reveals the relation of RCC1 to multiple immune checkpoint genes and suggests that the regulation of RCC1 is closely related to tumor infiltration of cancer-associated fibroblasts and CD8<sup>+</sup> T cells. Coherent data demonstrate the association of RCC1 with the tumor mutation burden and microsatellite instability in various tumors. These findings provide new insights into the role of RCC1 in oncogenesis and tumor immunology in various tumors and indicate its potential as marker for therapy prognosis and targeted treatment strategies.https://www.mdpi.com/1422-0067/22/14/7374RCC1pancancerprognosistumorimmune infiltrationenrichment analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Changwu Wu Yingjuan Duan Siming Gong Sonja Kallendrusch Nikolas Schopow Georg Osterhoff |
spellingShingle |
Changwu Wu Yingjuan Duan Siming Gong Sonja Kallendrusch Nikolas Schopow Georg Osterhoff Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1) International Journal of Molecular Sciences RCC1 pancancer prognosis tumor immune infiltration enrichment analysis |
author_facet |
Changwu Wu Yingjuan Duan Siming Gong Sonja Kallendrusch Nikolas Schopow Georg Osterhoff |
author_sort |
Changwu Wu |
title |
Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1) |
title_short |
Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1) |
title_full |
Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1) |
title_fullStr |
Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1) |
title_full_unstemmed |
Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1) |
title_sort |
integrative and comprehensive pancancer analysis of regulator of chromatin condensation 1 (rcc1) |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-07-01 |
description |
Regulator of Chromatin Condensation 1 (RCC1) is the only known guanine nucleotide exchange factor that acts on the Ras-like G protein Ran and plays a key role in cell cycle regulation. Although there is growing evidence to support the relationship between RCC1 and cancer, detailed pancancer analyses have not yet been performed. In this genome database study, based on The Cancer Genome Atlas, Genotype-Tissue Expression and Gene Expression Omnibus databases, the potential role of RCC1 in 33 tumors’ entities was explored. The results show that RCC1 is highly expressed in most human malignant neoplasms in contrast to healthy tissues. RCC1 expression is closely related to the prognosis of a broad variety of tumor patients. Enrichment analysis showed that some tumor-related pathways such as “cell cycle” and “RNA transport” were involved in the functional mechanism of RCC1. In particular, the conducted analysis reveals the relation of RCC1 to multiple immune checkpoint genes and suggests that the regulation of RCC1 is closely related to tumor infiltration of cancer-associated fibroblasts and CD8<sup>+</sup> T cells. Coherent data demonstrate the association of RCC1 with the tumor mutation burden and microsatellite instability in various tumors. These findings provide new insights into the role of RCC1 in oncogenesis and tumor immunology in various tumors and indicate its potential as marker for therapy prognosis and targeted treatment strategies. |
topic |
RCC1 pancancer prognosis tumor immune infiltration enrichment analysis |
url |
https://www.mdpi.com/1422-0067/22/14/7374 |
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