The Metabolism of Glucosinolates by Gut Microbiota
Glucosinolates (GLS) and their derivatives are secondary plant metabolites abundant in <i>Brassicaceae</i>. Due to the enzymatic reaction between GLS and myrosinase enzyme, characteristic compounds with a pungent taste are formed, used by plants to defend themselves against insect herbiv...
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doaj-64d66a24bf9f41d28379c3e5d4de4d592021-08-26T14:10:48ZengMDPI AGNutrients2072-66432021-08-01132750275010.3390/nu13082750The Metabolism of Glucosinolates by Gut MicrobiotaKalina Sikorska-Zimny0Luciano Beneduce1Fruit and Vegetables Storage and Processing Department, Division of Fruit and Vegetable Storage and Postharvest Physiology, The National Institute of Horticultural Research, Pomologiczna 13a Street, 96-100 Skierniewice, PolandDepartment of the Sciences of Agriculture, Food, Natural Resources, and Engineering (DAFNE) the University of Foggia, Via Napoli 25, 71122 Foggia, ItalyGlucosinolates (GLS) and their derivatives are secondary plant metabolites abundant in <i>Brassicaceae</i>. Due to the enzymatic reaction between GLS and myrosinase enzyme, characteristic compounds with a pungent taste are formed, used by plants to defend themselves against insect herbivores. These GLS derivatives have an important impact on human health, including anti-inflammation and anti-cancer effects. However, GLS derivatives’ formation needs previous enzymatic reactions catalyzed by myrosinase enzyme. Many of the brassica-based foods are processed at a high temperature that inactivates enzymes, hindering its bioavailability. In the last decade, several studies showed that the human gut microbiome can provide myrosinase activity that potentially can raise the beneficial effects of consumption of vegetables rich in GLS. The variability of the human gut microbiome (HGM) in human populations and the diverse intake of GLS through the diet may lead to greater variability of the real dose of pro-healthy compounds absorbed by the human body. The exploitation of the genetic and biochemical potential of HGM and correct ecological studies of both isolated strains and mixed population are of great interest. This review focuses on the most recent advances in this field.https://www.mdpi.com/2072-6643/13/8/2750glucosinolatesdietmicrobiota |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kalina Sikorska-Zimny Luciano Beneduce |
spellingShingle |
Kalina Sikorska-Zimny Luciano Beneduce The Metabolism of Glucosinolates by Gut Microbiota Nutrients glucosinolates diet microbiota |
author_facet |
Kalina Sikorska-Zimny Luciano Beneduce |
author_sort |
Kalina Sikorska-Zimny |
title |
The Metabolism of Glucosinolates by Gut Microbiota |
title_short |
The Metabolism of Glucosinolates by Gut Microbiota |
title_full |
The Metabolism of Glucosinolates by Gut Microbiota |
title_fullStr |
The Metabolism of Glucosinolates by Gut Microbiota |
title_full_unstemmed |
The Metabolism of Glucosinolates by Gut Microbiota |
title_sort |
metabolism of glucosinolates by gut microbiota |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-08-01 |
description |
Glucosinolates (GLS) and their derivatives are secondary plant metabolites abundant in <i>Brassicaceae</i>. Due to the enzymatic reaction between GLS and myrosinase enzyme, characteristic compounds with a pungent taste are formed, used by plants to defend themselves against insect herbivores. These GLS derivatives have an important impact on human health, including anti-inflammation and anti-cancer effects. However, GLS derivatives’ formation needs previous enzymatic reactions catalyzed by myrosinase enzyme. Many of the brassica-based foods are processed at a high temperature that inactivates enzymes, hindering its bioavailability. In the last decade, several studies showed that the human gut microbiome can provide myrosinase activity that potentially can raise the beneficial effects of consumption of vegetables rich in GLS. The variability of the human gut microbiome (HGM) in human populations and the diverse intake of GLS through the diet may lead to greater variability of the real dose of pro-healthy compounds absorbed by the human body. The exploitation of the genetic and biochemical potential of HGM and correct ecological studies of both isolated strains and mixed population are of great interest. This review focuses on the most recent advances in this field. |
topic |
glucosinolates diet microbiota |
url |
https://www.mdpi.com/2072-6643/13/8/2750 |
work_keys_str_mv |
AT kalinasikorskazimny themetabolismofglucosinolatesbygutmicrobiota AT lucianobeneduce themetabolismofglucosinolatesbygutmicrobiota AT kalinasikorskazimny metabolismofglucosinolatesbygutmicrobiota AT lucianobeneduce metabolismofglucosinolatesbygutmicrobiota |
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