Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
Macrophage specific deletion of GGTase-I, a prenylation enzyme, in mice induces inflammatory response and rheumatoid arthritis. Here the authors show that GGTase-I deficiency and the resulting reduction of RAC1 prenylation increase RAC1 interaction with the adaptor protein IQGAP1, leading to GTP-loa...
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Bibliographic Details
| Main Authors: |
Murali K. Akula,
Mohamed X. Ibrahim,
Emil G. Ivarsson,
Omar M. Khan,
Israiel T. Kumar,
Malin Erlandsson,
Christin Karlsson,
Xiufeng Xu,
Mikael Brisslert,
Cord Brakebusch,
Donghai Wang,
Maria Bokarewa,
Volkan I. Sayin,
Martin O. Bergo |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2019-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-11606-x
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