Large Animal Models: The Key to Translational Discovery in Digestive Disease ResearchSummary
Gastrointestinal disease is a prevalent cause of morbidity and mortality and the use of animal models have been instrumental in studying mechanisms of digestive pathophysiology. As investigators attempt to translate the wealth of basic science information developed from rodent models, large animal m...
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doaj-64e7e4b290e840c4ad6aa3dbd4b9337d2020-11-24T23:56:18ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2016-11-0126716724Large Animal Models: The Key to Translational Discovery in Digestive Disease ResearchSummaryAmanda Ziegler0Liara Gonzalez1Anthony Blikslager2Center for Gastrointestinal Biology and Disease, College of Veterinary Medicine, North Carolina State University, Raleigh, North CarolinaCenter for Gastrointestinal Biology and Disease, College of Veterinary Medicine, North Carolina State University, Raleigh, North CarolinaCorrespondence Address correspondence to: Anthony Blikslager, DVM, PhD, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, North Carolina 27607. fax: (919) 513â6464.; Center for Gastrointestinal Biology and Disease, College of Veterinary Medicine, North Carolina State University, Raleigh, North CarolinaGastrointestinal disease is a prevalent cause of morbidity and mortality and the use of animal models have been instrumental in studying mechanisms of digestive pathophysiology. As investigators attempt to translate the wealth of basic science information developed from rodent models, large animal models provide a number of translational advantages. The pig, in particular, is arguably one of the most powerful models of human organ systems, including the gastrointestinal tract. The pig has provided important tools and insight into intestinal ischemia/reperfusion injury, intestinal mucosal repair, as well as new insights into esophageal injury and repair. Porcine model development has taken advantage of the size of the animal, allowing increased surgical and endoscopic access. In addition, cellular tools such as the intestinal porcine epithelial cell (IPEC-J2) line and porcine enteroids are providing the methodology to translate basic science findings using in-depth mechanistic analyses. Further opportunities in porcine digestive disease modeling include developing additional transgenic pig strains. Collectively, porcine models hold great promise for the future of clinically relevant digestive disease research. Keywords: Pig, Ischemia/Reperfusion Injury, Mucosal Repair, Tight Junctionhttp://www.sciencedirect.com/science/article/pii/S2352345X16301047 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amanda Ziegler Liara Gonzalez Anthony Blikslager |
spellingShingle |
Amanda Ziegler Liara Gonzalez Anthony Blikslager Large Animal Models: The Key to Translational Discovery in Digestive Disease ResearchSummary Cellular and Molecular Gastroenterology and Hepatology |
author_facet |
Amanda Ziegler Liara Gonzalez Anthony Blikslager |
author_sort |
Amanda Ziegler |
title |
Large Animal Models: The Key to Translational Discovery in Digestive Disease ResearchSummary |
title_short |
Large Animal Models: The Key to Translational Discovery in Digestive Disease ResearchSummary |
title_full |
Large Animal Models: The Key to Translational Discovery in Digestive Disease ResearchSummary |
title_fullStr |
Large Animal Models: The Key to Translational Discovery in Digestive Disease ResearchSummary |
title_full_unstemmed |
Large Animal Models: The Key to Translational Discovery in Digestive Disease ResearchSummary |
title_sort |
large animal models: the key to translational discovery inâ digestive disease researchsummary |
publisher |
Elsevier |
series |
Cellular and Molecular Gastroenterology and Hepatology |
issn |
2352-345X |
publishDate |
2016-11-01 |
description |
Gastrointestinal disease is a prevalent cause of morbidity and mortality and the use of animal models have been instrumental in studying mechanisms of digestive pathophysiology. As investigators attempt to translate the wealth of basic science information developed from rodent models, large animal models provide a number of translational advantages. The pig, in particular, is arguably one of the most powerful models of human organ systems, including the gastrointestinal tract. The pig has provided important tools and insight into intestinal ischemia/reperfusion injury, intestinal mucosal repair, as well as new insights into esophageal injury and repair. Porcine model development has taken advantage of the size of the animal, allowing increased surgical and endoscopic access. In addition, cellular tools such as the intestinal porcine epithelial cell (IPEC-J2) line and porcine enteroids are providing the methodology to translate basic science findings using in-depth mechanistic analyses. Further opportunities in porcine digestive disease modeling include developing additional transgenic pig strains. Collectively, porcine models hold great promise for the future of clinically relevant digestive disease research. Keywords: Pig, Ischemia/Reperfusion Injury, Mucosal Repair, Tight Junction |
url |
http://www.sciencedirect.com/science/article/pii/S2352345X16301047 |
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