Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells

Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells

Abstract β-cell proliferation induction is a promising therapeutic strategy to restore β-cell mass. By screening small molecules in a transgenic zebrafish model of type 1 diabetes, we identified inhibitors of non-canonical IκB kinases (IKKs), TANK-binding kinase 1 (TBK1) and IκB kinase ε (IKKε), as...

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Bibliographic Details
Main Authors: Jin Xu, Yun-Fang Jia, Subhasish Tapadar, Jessica D. Weaver, Idris O. Raji, Deeti J. Pithadia, Naureen Javeed, Andrés J. García, Doo-Sup Choi, Aleksey V. Matveyenko, Adegboyega K. Oyelere, Chong Hyun Shin
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Scientific Reports
Subjects:
TANK-binding Kinase 1 (TBK1)
Transgenic Zebrafish Model
Isoxazolyl
Supplemental Experimental Procedures
Amlexanox
Online Access:https://doi.org/10.1038/s41598-018-33875-0

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