Improved stability and controlled release of lutein-loaded micelles based on glycosylated casein via Maillard reaction
Lutein was encapsulated in glycosylated micelles and the controlled delivery property was investigated. The particle size at different pH and CaCl2 concentration showed that the stability of micelles based on glycosylated casein was significantly superior to that of casein/dextran mixture. The bigge...
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doaj-64eb8a0cc1824ba4a665e80d551f3dd42021-04-30T07:13:21ZengElsevierJournal of Functional Foods1756-46462018-06-014519Improved stability and controlled release of lutein-loaded micelles based on glycosylated casein via Maillard reactionBertrand Muhoza0Yating Zhang1Shuqin Xia2Jibao Cai3Xiaoming Zhang4Jiakun Su5State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Lihu Road 1800, Wuxi, Jiangsu 214122, People’s Republic of ChinaState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Lihu Road 1800, Wuxi, Jiangsu 214122, People’s Republic of ChinaState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Lihu Road 1800, Wuxi, Jiangsu 214122, People’s Republic of China; Center of R&D, China Tobacco Jiangxi Industrial Co. Ltd., Nanchang 330096, People’s Republic of China; Corresponding author at: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Lihu Road 1800, Wuxi, Jiangsu 214122, People’s Republic of China (S. Xia).Center of R&D, China Tobacco Jiangxi Industrial Co. Ltd., Nanchang 330096, People’s Republic of China; Corresponding author at: Center of R&D, China Tobacco Jiangxi Industrial Co. Ltd., Nanchang, Jiangxi 330096, People’s Republic of China (J. Cai).State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Lihu Road 1800, Wuxi, Jiangsu 214122, People’s Republic of ChinaCenter of R&D, China Tobacco Jiangxi Industrial Co. Ltd., Nanchang 330096, People’s Republic of ChinaLutein was encapsulated in glycosylated micelles and the controlled delivery property was investigated. The particle size at different pH and CaCl2 concentration showed that the stability of micelles based on glycosylated casein was significantly superior to that of casein/dextran mixture. The bigger molecular weight of the dextran moieties attached to the casein molecules improved the steric hindrance effect. The cumulative release rate showed that lutein could be bound with glycosylated casein in the micelles and uniformly scattered in simulated gastric fluid, while micelles composed of casein and dextran mixtures rapidly disintegrated and released the embedding lutein within 0.5 h. Additionally, micelles based on glycosylated casein significantly increased the bioaccessibility of lutein from 14.63% to 62.45%. Therefore, glycosylated casein via Maillard reaction could be used as the carrier of lutein, which might effectively control its release behavior in the simulated gastrointestinal tract.http://www.sciencedirect.com/science/article/pii/S175646461830121XCaseinDextranLuteinSimulated gastrointestinal fluidControlled release |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bertrand Muhoza Yating Zhang Shuqin Xia Jibao Cai Xiaoming Zhang Jiakun Su |
spellingShingle |
Bertrand Muhoza Yating Zhang Shuqin Xia Jibao Cai Xiaoming Zhang Jiakun Su Improved stability and controlled release of lutein-loaded micelles based on glycosylated casein via Maillard reaction Journal of Functional Foods Casein Dextran Lutein Simulated gastrointestinal fluid Controlled release |
author_facet |
Bertrand Muhoza Yating Zhang Shuqin Xia Jibao Cai Xiaoming Zhang Jiakun Su |
author_sort |
Bertrand Muhoza |
title |
Improved stability and controlled release of lutein-loaded micelles based on glycosylated casein via Maillard reaction |
title_short |
Improved stability and controlled release of lutein-loaded micelles based on glycosylated casein via Maillard reaction |
title_full |
Improved stability and controlled release of lutein-loaded micelles based on glycosylated casein via Maillard reaction |
title_fullStr |
Improved stability and controlled release of lutein-loaded micelles based on glycosylated casein via Maillard reaction |
title_full_unstemmed |
Improved stability and controlled release of lutein-loaded micelles based on glycosylated casein via Maillard reaction |
title_sort |
improved stability and controlled release of lutein-loaded micelles based on glycosylated casein via maillard reaction |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2018-06-01 |
description |
Lutein was encapsulated in glycosylated micelles and the controlled delivery property was investigated. The particle size at different pH and CaCl2 concentration showed that the stability of micelles based on glycosylated casein was significantly superior to that of casein/dextran mixture. The bigger molecular weight of the dextran moieties attached to the casein molecules improved the steric hindrance effect. The cumulative release rate showed that lutein could be bound with glycosylated casein in the micelles and uniformly scattered in simulated gastric fluid, while micelles composed of casein and dextran mixtures rapidly disintegrated and released the embedding lutein within 0.5 h. Additionally, micelles based on glycosylated casein significantly increased the bioaccessibility of lutein from 14.63% to 62.45%. Therefore, glycosylated casein via Maillard reaction could be used as the carrier of lutein, which might effectively control its release behavior in the simulated gastrointestinal tract. |
topic |
Casein Dextran Lutein Simulated gastrointestinal fluid Controlled release |
url |
http://www.sciencedirect.com/science/article/pii/S175646461830121X |
work_keys_str_mv |
AT bertrandmuhoza improvedstabilityandcontrolledreleaseofluteinloadedmicellesbasedonglycosylatedcaseinviamaillardreaction AT yatingzhang improvedstabilityandcontrolledreleaseofluteinloadedmicellesbasedonglycosylatedcaseinviamaillardreaction AT shuqinxia improvedstabilityandcontrolledreleaseofluteinloadedmicellesbasedonglycosylatedcaseinviamaillardreaction AT jibaocai improvedstabilityandcontrolledreleaseofluteinloadedmicellesbasedonglycosylatedcaseinviamaillardreaction AT xiaomingzhang improvedstabilityandcontrolledreleaseofluteinloadedmicellesbasedonglycosylatedcaseinviamaillardreaction AT jiakunsu improvedstabilityandcontrolledreleaseofluteinloadedmicellesbasedonglycosylatedcaseinviamaillardreaction |
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1721499308305416192 |