Prognostic role of the advanced lung cancer inflammation index in cancer patients: a meta-analysis
Abstract Background Inflammation plays a critical role in the development and progression of cancers. The advanced lung cancer inflammation index (ALI) is thought to be able to reflect systemic inflammation better than current biomarkers. However, the prognostic significance of the ALI in various ty...
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doaj-64ef489afbf348faaca9cb25378a951c2020-11-25T03:58:30ZengBMCWorld Journal of Surgical Oncology1477-78192019-11-011711910.1186/s12957-019-1725-2Prognostic role of the advanced lung cancer inflammation index in cancer patients: a meta-analysisXin Hua0Jing Chen1Ying Wu2Jun Sha3Shuhua Han4Xiaoli Zhu5Medical School of Southeast UniversityDepartment of Respiratory, Zhongda Hospital of Southeast UniversityDepartment of Respiratory, Zhongda Hospital of Southeast UniversityMedical School of Southeast UniversityDepartment of Respiratory, Zhongda Hospital of Southeast UniversityMedical School of Southeast UniversityAbstract Background Inflammation plays a critical role in the development and progression of cancers. The advanced lung cancer inflammation index (ALI) is thought to be able to reflect systemic inflammation better than current biomarkers. However, the prognostic significance of the ALI in various types of cancer remains unclear. Our meta-analysis aimed to comprehensively investigate the relationship between the ALI and oncologic outcomes to help physicians better assess the prognosis of cancer patients. Methods The PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases were searched for relevant studies. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated and pooled from the included studies. Furthermore, a sensitivity analysis was performed to evaluate the reliability of the articles. Finally, Begg’s test, Egger’s test, and the funnel plot were applied to assess the significance of publication bias. Results In total, 1736 patients from nine studies were included in our meta-analysis. The median cutoff value for the ALI was 23.2 (range, 15.5–37.66) in the analyzed studies. The meta-analysis showed that there was a statistically significant relationship between a low ALI and worse overall survival (OS) in various types of cancer (HR = 1.70, 95% CI = 1.41–1.99, P < 0.001). Moreover, results from subgroup meta-analysis showed that the ALI had a significant prognostic value in non-small cell lung cancer, small cell lung cancer, colorectal cancer, head and neck squamous cell carcinoma, and diffuse large B cell lymphoma (P < 0.05 for all). Conclusions These results showed that a low ALI was associated with poor OS in various types of cancer, and the ALI could act as an effective prognostic biomarker in cancer patients.http://link.springer.com/article/10.1186/s12957-019-1725-2CancerMeta-analysisAdvanced lung cancer inflammation index (ALI)Prognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xin Hua Jing Chen Ying Wu Jun Sha Shuhua Han Xiaoli Zhu |
spellingShingle |
Xin Hua Jing Chen Ying Wu Jun Sha Shuhua Han Xiaoli Zhu Prognostic role of the advanced lung cancer inflammation index in cancer patients: a meta-analysis World Journal of Surgical Oncology Cancer Meta-analysis Advanced lung cancer inflammation index (ALI) Prognosis |
author_facet |
Xin Hua Jing Chen Ying Wu Jun Sha Shuhua Han Xiaoli Zhu |
author_sort |
Xin Hua |
title |
Prognostic role of the advanced lung cancer inflammation index in cancer patients: a meta-analysis |
title_short |
Prognostic role of the advanced lung cancer inflammation index in cancer patients: a meta-analysis |
title_full |
Prognostic role of the advanced lung cancer inflammation index in cancer patients: a meta-analysis |
title_fullStr |
Prognostic role of the advanced lung cancer inflammation index in cancer patients: a meta-analysis |
title_full_unstemmed |
Prognostic role of the advanced lung cancer inflammation index in cancer patients: a meta-analysis |
title_sort |
prognostic role of the advanced lung cancer inflammation index in cancer patients: a meta-analysis |
publisher |
BMC |
series |
World Journal of Surgical Oncology |
issn |
1477-7819 |
publishDate |
2019-11-01 |
description |
Abstract Background Inflammation plays a critical role in the development and progression of cancers. The advanced lung cancer inflammation index (ALI) is thought to be able to reflect systemic inflammation better than current biomarkers. However, the prognostic significance of the ALI in various types of cancer remains unclear. Our meta-analysis aimed to comprehensively investigate the relationship between the ALI and oncologic outcomes to help physicians better assess the prognosis of cancer patients. Methods The PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases were searched for relevant studies. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated and pooled from the included studies. Furthermore, a sensitivity analysis was performed to evaluate the reliability of the articles. Finally, Begg’s test, Egger’s test, and the funnel plot were applied to assess the significance of publication bias. Results In total, 1736 patients from nine studies were included in our meta-analysis. The median cutoff value for the ALI was 23.2 (range, 15.5–37.66) in the analyzed studies. The meta-analysis showed that there was a statistically significant relationship between a low ALI and worse overall survival (OS) in various types of cancer (HR = 1.70, 95% CI = 1.41–1.99, P < 0.001). Moreover, results from subgroup meta-analysis showed that the ALI had a significant prognostic value in non-small cell lung cancer, small cell lung cancer, colorectal cancer, head and neck squamous cell carcinoma, and diffuse large B cell lymphoma (P < 0.05 for all). Conclusions These results showed that a low ALI was associated with poor OS in various types of cancer, and the ALI could act as an effective prognostic biomarker in cancer patients. |
topic |
Cancer Meta-analysis Advanced lung cancer inflammation index (ALI) Prognosis |
url |
http://link.springer.com/article/10.1186/s12957-019-1725-2 |
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