Peptide YY (PYY) Is Associated with Cardiovascular Risk in Patients with Acute Myocardial Infarction
Aims: Recent studies have found circulating concentrations of the gastrointestinal hormone GLP-1 to be an excellent predictor of cardiovascular risk in patients with myocardial infarction. This illustrates a yet not appreciated crosstalk between the gastrointestinal and cardiovascular systems, which...
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doaj-64f3456c6c144c18ba6443ebc5c77fed2020-12-07T00:00:30ZengMDPI AGJournal of Clinical Medicine2077-03832020-12-0193952395210.3390/jcm9123952Peptide YY (PYY) Is Associated with Cardiovascular Risk in Patients with Acute Myocardial InfarctionElias Haj-Yehia0Robert Werner Mertens1Florian Kahles2Marcia Viviane Rückbeil3Matthias Rau4Julia Moellmann5Moritz Biener6Mohammad Almalla7Jörg Schroeder8Evangelos Giannitsis9Hugo Albert Katus10Nikolaus Marx11Michael Lehrke12Department of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, GermanyDepartment of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, GermanyDepartment of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, GermanyDepartment of Medical Statistics, University Hospital Aachen, Pauwelsstraße 19, 52074 Aachen, GermanyDepartment of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, GermanyDepartment of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, GermanyDepartment of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, GermanyDepartment of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, GermanyDepartment of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, GermanyDepartment of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, GermanyDepartment of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, GermanyDepartment of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, GermanyDepartment of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, GermanyAims: Recent studies have found circulating concentrations of the gastrointestinal hormone GLP-1 to be an excellent predictor of cardiovascular risk in patients with myocardial infarction. This illustrates a yet not appreciated crosstalk between the gastrointestinal and cardiovascular systems, which requires further investigation. The gut-derived hormone Peptide YY (PYY) is secreted from the same intestinal L-cells as GLP-1. Relevance of PYY in the context of cardiovascular disease has not been explored. In this study, we aimed to investigate PYY serum concentrations in patients with acute myocardial infarction and to evaluate their association with cardiovascular events. Material and Methods: PYY levels were assessed in 834 patients presenting with acute myocardial infarction (553 Non-ST-Elevation Myocardial Infarction (NSTEMI) and 281 ST-Elevation Myocardial Infarction (STEMI)) at the time of hospital admission. The composite outcomes of first occurrence of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke (3-P-MACE), and all-cause mortality were assessed with a median follow-up of 338 days. Results: PYY levels were significantly associated with age and cardiovascular risk factors, including hypertension, diabetes, and kidney function in addition to biomarkers of heart failure (NT-pro BNP) and inflammation (hs-CRP). Further, PYY was significantly associated with 3-P-MACE (HR: 1.7; 95% CI: 1–2.97; <i>p</i> = 0.0495) and all-cause mortality (HR: 2.69; 95% CI: 1.61–4.47; <i>p</i> = 0.0001) by univariable Cox regression analyses, which was however lost after adjusting for multiple confounders. Conclusions: PYY levels are associated with parameters of cardiovascular risk as well as cardiovascular events and mortality in patients presenting with acute myocardial infarction. However, this significant association is lost after adjustment for further confounders.https://www.mdpi.com/2077-0383/9/12/3952PYYgut hormonecardiovascular riskmortalitymyocardial infarction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elias Haj-Yehia Robert Werner Mertens Florian Kahles Marcia Viviane Rückbeil Matthias Rau Julia Moellmann Moritz Biener Mohammad Almalla Jörg Schroeder Evangelos Giannitsis Hugo Albert Katus Nikolaus Marx Michael Lehrke |
spellingShingle |
Elias Haj-Yehia Robert Werner Mertens Florian Kahles Marcia Viviane Rückbeil Matthias Rau Julia Moellmann Moritz Biener Mohammad Almalla Jörg Schroeder Evangelos Giannitsis Hugo Albert Katus Nikolaus Marx Michael Lehrke Peptide YY (PYY) Is Associated with Cardiovascular Risk in Patients with Acute Myocardial Infarction Journal of Clinical Medicine PYY gut hormone cardiovascular risk mortality myocardial infarction |
author_facet |
Elias Haj-Yehia Robert Werner Mertens Florian Kahles Marcia Viviane Rückbeil Matthias Rau Julia Moellmann Moritz Biener Mohammad Almalla Jörg Schroeder Evangelos Giannitsis Hugo Albert Katus Nikolaus Marx Michael Lehrke |
author_sort |
Elias Haj-Yehia |
title |
Peptide YY (PYY) Is Associated with Cardiovascular Risk in Patients with Acute Myocardial Infarction |
title_short |
Peptide YY (PYY) Is Associated with Cardiovascular Risk in Patients with Acute Myocardial Infarction |
title_full |
Peptide YY (PYY) Is Associated with Cardiovascular Risk in Patients with Acute Myocardial Infarction |
title_fullStr |
Peptide YY (PYY) Is Associated with Cardiovascular Risk in Patients with Acute Myocardial Infarction |
title_full_unstemmed |
Peptide YY (PYY) Is Associated with Cardiovascular Risk in Patients with Acute Myocardial Infarction |
title_sort |
peptide yy (pyy) is associated with cardiovascular risk in patients with acute myocardial infarction |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-12-01 |
description |
Aims: Recent studies have found circulating concentrations of the gastrointestinal hormone GLP-1 to be an excellent predictor of cardiovascular risk in patients with myocardial infarction. This illustrates a yet not appreciated crosstalk between the gastrointestinal and cardiovascular systems, which requires further investigation. The gut-derived hormone Peptide YY (PYY) is secreted from the same intestinal L-cells as GLP-1. Relevance of PYY in the context of cardiovascular disease has not been explored. In this study, we aimed to investigate PYY serum concentrations in patients with acute myocardial infarction and to evaluate their association with cardiovascular events. Material and Methods: PYY levels were assessed in 834 patients presenting with acute myocardial infarction (553 Non-ST-Elevation Myocardial Infarction (NSTEMI) and 281 ST-Elevation Myocardial Infarction (STEMI)) at the time of hospital admission. The composite outcomes of first occurrence of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke (3-P-MACE), and all-cause mortality were assessed with a median follow-up of 338 days. Results: PYY levels were significantly associated with age and cardiovascular risk factors, including hypertension, diabetes, and kidney function in addition to biomarkers of heart failure (NT-pro BNP) and inflammation (hs-CRP). Further, PYY was significantly associated with 3-P-MACE (HR: 1.7; 95% CI: 1–2.97; <i>p</i> = 0.0495) and all-cause mortality (HR: 2.69; 95% CI: 1.61–4.47; <i>p</i> = 0.0001) by univariable Cox regression analyses, which was however lost after adjusting for multiple confounders. Conclusions: PYY levels are associated with parameters of cardiovascular risk as well as cardiovascular events and mortality in patients presenting with acute myocardial infarction. However, this significant association is lost after adjustment for further confounders. |
topic |
PYY gut hormone cardiovascular risk mortality myocardial infarction |
url |
https://www.mdpi.com/2077-0383/9/12/3952 |
work_keys_str_mv |
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