Research progress on markers of urine tubular damage in idiopathic membranous nephropathy

• Main Authors: http://www.hnykdxxb.com/PDF/202117/01.pdf, Feng-Wen Yang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2021-08-01
• Series: Journal of Hainan Medical University
• Subjects: idiopathic membranous nephropathy; n-acetyl-β-d-glucosaminidase; retinol binding protein; kidney injury molecule 1; neutrophil gelatinase-associated lipoprotein; liver-type fatty acid binding protein
• Online Access: http://www.hnykdxxb.com/PDF/202117/13.pdf

Idiopathic membranous nephropathy is a common primary glomerular disease. Recently, it has been found that the progression and prognosis of glomerular diseases are not only related to the glomeruli itself, but also to the severity of renal tubular injury. Although blood creatinine and urinary protein are recognized biomarkers, they appear late, are insensitive, lack specificity, and are difficult to respond to IMN conditions in a timely and accurate manner. Markers such as N-acetyl-β-D-glucosaminidase, kidney injury molecule 1, neutrophil gelatinase-associated lipoprotein in urine can dynamically reflect the progress of kidney injury in the early stage, and are detected as noninvasive, so It has been applied in IMN, but such research is lacking, and the scope needs to be further expanded and discussed in depth.