KEA-1010, a ketamine ester analogue, retains analgesic and sedative potency but is devoid of Psychomimetic effects
Abstract Background Ketamine, a widely used anaesthetic and analgesic agent, is known to improve the analgesic efficacy of opioids and to attenuate central sensitisation and opioid-induced hyperalgesia. Clinical use is, however, curtailed by unwanted psychomimetic effects thought to be mediated by N...
Main Authors: | Martyn Harvey, Jamie Sleigh, Logan Voss, Mike Bickerdike, Ivaylo Dimitrov, William Denny |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2019-12-01
|
Series: | BMC Pharmacology and Toxicology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s40360-019-0374-y |
Similar Items
-
Structure-Activity Relationships for the Anaesthetic and Analgaesic Properties of Aromatic Ring-Substituted Ketamine Esters
by: Ivaylo V. Dimitrov, et al.
Published: (2020-06-01) -
Comparative efficacy of Diazepam, Ketamine, and Diazepam-Ketamine combination for sedation or anesthesia in cockerel chickens
by: Muhammad Abdullahi Mahmud, et al.
Published: (2014-09-01) -
Ketamine Sedation of Case with Unknown Posterior Fossa Tumor
by: Bengü Gülhan Aydın, et al.
Published: (2016-09-01) -
Ketamine for continuous sedation of mechanically ventilated patients
by: Ben-Paul Umunna, et al.
Published: (2015-01-01) -
Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain
by: Gregory M. Jacobson, et al.
Published: (2019-04-01)