High density lipoprotein as a source of cholesterol for adrenal steroidogenesis: a study in individuals with low plasma HDL-C
Few studies have addressed the delivery of lipoprotein-derived cholesterol to the adrenals for steroid production in humans. While there is evidence against a role for low-density lipoprotein (LDL), it is unresolved whether high density lipoprotein (HDL) contributes to adrenal steroidogenesis. To st...
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doaj-65102de4b9844bf8ad15c2a87416c7412021-04-28T06:01:11ZengElsevierJournal of Lipid Research0022-22752013-06-0154616981704High density lipoprotein as a source of cholesterol for adrenal steroidogenesis: a study in individuals with low plasma HDL-CAndrea E. Bochem0Adriaan G. Holleboom1Johannes A. Romijn2Menno Hoekstra3Geesje M. Dallinga-Thie4Mahdi M. Motazacker5G.Kees Hovingh6Jan A. Kuivenhoven7Erik S.G. Stroes8To whom correspondence should be addressed; Departments of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands; To whom correspondence should be addressedDepartments of Vascular Medicine, Academic Medical Center, Amsterdam, The NetherlandsDepartments of Medicine, Academic Medical Center, Amsterdam, The NetherlandsLeiden/Amsterdam Center for Drug Research, Leiden, The NetherlandsDepartments of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands; Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The NetherlandsDepartments of Medicine, Academic Medical Center, Amsterdam, The NetherlandsDepartments of Vascular Medicine, Academic Medical Center, Amsterdam, The NetherlandsDepartment of Pathology and Medical Biology, Department of Molecular Genetics, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsDepartments of Vascular Medicine, Academic Medical Center, Amsterdam, The NetherlandsFew studies have addressed the delivery of lipoprotein-derived cholesterol to the adrenals for steroid production in humans. While there is evidence against a role for low-density lipoprotein (LDL), it is unresolved whether high density lipoprotein (HDL) contributes to adrenal steroidogenesis. To study this, steroid hormone profiles in urine were assessed in male subjects suffering from functional mutations in ATP binding cassette transporter A1 (ABCA1) (n = 24), lecithin:cholesterol acyltransferase (LCAT) (n = 40), as well as in 11 subjects with low HDL cholesterol (HDL-C) without ABCA1/LCAT mutations. HDL-C levels were 39% lower in the ABCA1, LCAT, and low HDL-C groups compared with controls (all P < 0.001). In all groups with low HDL-C levels, urinary excretion of 17-ketogenic steroids was reduced by 33%, 27%, and 32% compared with controls (all P < 0.04). In seven carriers of either type of mutation, adrenocorticotropic hormone (ACTH) stimulation did not reveal differences from normolipidemic controls. In conclusion, this study shows that basal but not stimulated corticosteroid metabolism is attenuated in subjects with low HDL-C, irrespective of its molecular origin. These findings lend support to a role for HDL as a cholesterol donor for basal adrenal steroidogenesis in humans.http://www.sciencedirect.com/science/article/pii/S0022227520357254steroid hormonescortisoldyslipidemiahypoalphalipoproteinemiahigh density lipoprotein cholesterol |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrea E. Bochem Adriaan G. Holleboom Johannes A. Romijn Menno Hoekstra Geesje M. Dallinga-Thie Mahdi M. Motazacker G.Kees Hovingh Jan A. Kuivenhoven Erik S.G. Stroes |
spellingShingle |
Andrea E. Bochem Adriaan G. Holleboom Johannes A. Romijn Menno Hoekstra Geesje M. Dallinga-Thie Mahdi M. Motazacker G.Kees Hovingh Jan A. Kuivenhoven Erik S.G. Stroes High density lipoprotein as a source of cholesterol for adrenal steroidogenesis: a study in individuals with low plasma HDL-C Journal of Lipid Research steroid hormones cortisol dyslipidemia hypoalphalipoproteinemia high density lipoprotein cholesterol |
author_facet |
Andrea E. Bochem Adriaan G. Holleboom Johannes A. Romijn Menno Hoekstra Geesje M. Dallinga-Thie Mahdi M. Motazacker G.Kees Hovingh Jan A. Kuivenhoven Erik S.G. Stroes |
author_sort |
Andrea E. Bochem |
title |
High density lipoprotein as a source of cholesterol for adrenal steroidogenesis: a study in individuals with low plasma HDL-C |
title_short |
High density lipoprotein as a source of cholesterol for adrenal steroidogenesis: a study in individuals with low plasma HDL-C |
title_full |
High density lipoprotein as a source of cholesterol for adrenal steroidogenesis: a study in individuals with low plasma HDL-C |
title_fullStr |
High density lipoprotein as a source of cholesterol for adrenal steroidogenesis: a study in individuals with low plasma HDL-C |
title_full_unstemmed |
High density lipoprotein as a source of cholesterol for adrenal steroidogenesis: a study in individuals with low plasma HDL-C |
title_sort |
high density lipoprotein as a source of cholesterol for adrenal steroidogenesis: a study in individuals with low plasma hdl-c |
publisher |
Elsevier |
series |
Journal of Lipid Research |
issn |
0022-2275 |
publishDate |
2013-06-01 |
description |
Few studies have addressed the delivery of lipoprotein-derived cholesterol to the adrenals for steroid production in humans. While there is evidence against a role for low-density lipoprotein (LDL), it is unresolved whether high density lipoprotein (HDL) contributes to adrenal steroidogenesis. To study this, steroid hormone profiles in urine were assessed in male subjects suffering from functional mutations in ATP binding cassette transporter A1 (ABCA1) (n = 24), lecithin:cholesterol acyltransferase (LCAT) (n = 40), as well as in 11 subjects with low HDL cholesterol (HDL-C) without ABCA1/LCAT mutations. HDL-C levels were 39% lower in the ABCA1, LCAT, and low HDL-C groups compared with controls (all P < 0.001). In all groups with low HDL-C levels, urinary excretion of 17-ketogenic steroids was reduced by 33%, 27%, and 32% compared with controls (all P < 0.04). In seven carriers of either type of mutation, adrenocorticotropic hormone (ACTH) stimulation did not reveal differences from normolipidemic controls. In conclusion, this study shows that basal but not stimulated corticosteroid metabolism is attenuated in subjects with low HDL-C, irrespective of its molecular origin. These findings lend support to a role for HDL as a cholesterol donor for basal adrenal steroidogenesis in humans. |
topic |
steroid hormones cortisol dyslipidemia hypoalphalipoproteinemia high density lipoprotein cholesterol |
url |
http://www.sciencedirect.com/science/article/pii/S0022227520357254 |
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