HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil
Laryngeal papillomatosis (LP) is a rare human papillomavirus (HPV) related disease that often requires multiple surgical interventions and residual impairment of voice is almost inevitable. We report the case of a patient with adult onset recurrent LP, showing moderate dysplasia and coinfection with...
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Series: | Case Reports in Otolaryngology |
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doaj-6514c67ac54a418997ce3b5f8f05a4ad2020-11-24T23:24:24ZengHindawi LimitedCase Reports in Otolaryngology2090-67652090-67732015-01-01201510.1155/2015/916023916023HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with GardasilVirginia Fancello0Andrea Melis1Andrea Fausto Piana2Paolo Castiglia3Andrea Cossu4Giovanni Sotgiu5Corrado Bozzo6Emma Victoria King7Francesco Meloni8Division of Otorhinolaryngology, Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Viale San Pietro 43, 07100 Sassari, ItalyDivision of Otorhinolaryngology, Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Viale San Pietro 43, 07100 Sassari, ItalyHygiene and Preventive Medicine, Department of Biomedical Sciences, University of Sassari, Sassari, ItalyHygiene and Preventive Medicine, Department of Biomedical Sciences, University of Sassari, Sassari, ItalyHygiene and Preventive Medicine, Department of Biomedical Sciences, University of Sassari, Sassari, ItalyHygiene and Preventive Medicine, Department of Biomedical Sciences, University of Sassari, Sassari, ItalyENT Department, P. Dettori Hospital, Tempio Pausania, ItalyDepartment of Head and Neck Surgery, Poole Hospital NHS Foundation Trust, Poole, UKDivision of Otorhinolaryngology, Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Viale San Pietro 43, 07100 Sassari, ItalyLaryngeal papillomatosis (LP) is a rare human papillomavirus (HPV) related disease that often requires multiple surgical interventions and residual impairment of voice is almost inevitable. We report the case of a patient with adult onset recurrent LP, showing moderate dysplasia and coinfection with HPV types 6 and 18. The tetravalent HPV vaccine Gardasil was prescribed off label, with the aim of triggering an immunogenic response and consequently reducing the probability of further recurrences. The patient was followed for 9 months with no sign of relapse of his LP. The postexposure use of the anti-HPV vaccine could represent a promising therapeutic agent in established LP. Unfortunately, the potential efficacy of this new therapeutic option in this situation has been suggested only by isolated case reports. Further controlled studies, with a longer follow-up and a larger sample size, are needed to assess efficacy of Gardasil in LP.http://dx.doi.org/10.1155/2015/916023 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Virginia Fancello Andrea Melis Andrea Fausto Piana Paolo Castiglia Andrea Cossu Giovanni Sotgiu Corrado Bozzo Emma Victoria King Francesco Meloni |
spellingShingle |
Virginia Fancello Andrea Melis Andrea Fausto Piana Paolo Castiglia Andrea Cossu Giovanni Sotgiu Corrado Bozzo Emma Victoria King Francesco Meloni HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil Case Reports in Otolaryngology |
author_facet |
Virginia Fancello Andrea Melis Andrea Fausto Piana Paolo Castiglia Andrea Cossu Giovanni Sotgiu Corrado Bozzo Emma Victoria King Francesco Meloni |
author_sort |
Virginia Fancello |
title |
HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil |
title_short |
HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil |
title_full |
HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil |
title_fullStr |
HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil |
title_full_unstemmed |
HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil |
title_sort |
hpv type 6 and 18 coinfection in a case of adult-onset laryngeal papillomatosis: immunization with gardasil |
publisher |
Hindawi Limited |
series |
Case Reports in Otolaryngology |
issn |
2090-6765 2090-6773 |
publishDate |
2015-01-01 |
description |
Laryngeal papillomatosis (LP) is a rare human papillomavirus (HPV) related disease that often requires multiple surgical interventions and residual impairment of voice is almost inevitable. We report the case of a patient with adult onset recurrent LP, showing moderate dysplasia and coinfection with HPV types 6 and 18. The tetravalent HPV vaccine Gardasil was prescribed off label, with the aim of triggering an immunogenic response and consequently reducing the probability of further recurrences. The patient was followed for 9 months with no sign of relapse of his LP. The postexposure use of the anti-HPV vaccine could represent a promising therapeutic agent in established LP. Unfortunately, the potential efficacy of this new therapeutic option in this situation has been suggested only by isolated case reports. Further controlled studies, with a longer follow-up and a larger sample size, are needed to assess efficacy of Gardasil in LP. |
url |
http://dx.doi.org/10.1155/2015/916023 |
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