Chemical and pharmacological investigation of Solanum species of Brazil: a search for solasodine and other potentially useful therapeutic agents
A systematic search for solasodine, an important staring material for the partial synthesis of steroidal hormones as well as other potentially bioactive constituents of various Solanum species of Brazil has been undertaken. Thus, the fruits of S. paludosum, S. asperum, S. sessiliforum and Solanum sp...
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Instituto Oswaldo Cruz, Ministério da Saúde
1991-01-01
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Series: | Memórias do Instituto Oswaldo Cruz. |
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600043 |
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doaj-6515fa28e14f47eab54bac9f8243fb4e2020-11-24T23:39:51ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.0074-02761678-80601991-01-018618919110.1590/S0074-02761991000600043Chemical and pharmacological investigation of Solanum species of Brazil: a search for solasodine and other potentially useful therapeutic agentsJ. M. Barbosa FilhoM. F. AgraR. A. G. OliveiraM. Q. PauloG. TrolinE. V. L. CunhaJ. R. AtaideJ. BhattacharyyaA systematic search for solasodine, an important staring material for the partial synthesis of steroidal hormones as well as other potentially bioactive constituents of various Solanum species of Brazil has been undertaken. Thus, the fruits of S. paludosum, S. asperum, S. sessiliforum and Solanum sp. were found to contain significant amounts of solasodine. The root bark of S. paludosum which showe durare like activity yelded tomatidenol and another yet unidentified alkaloid responsible for the biological activity. The fruits of S. asperum yelded a new spirosolane alkaloid, solaparnaine. The stem bark of S. pseudo-quina showed convulsive and exitatory activity from which (25S)-isosolafloridine was identified as the active principle. In addition, the latter alkaloid was also found to show antimicrobial activity.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600043soladinesteroidal hormonesSolanumalkaloid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
J. M. Barbosa Filho M. F. Agra R. A. G. Oliveira M. Q. Paulo G. Trolin E. V. L. Cunha J. R. Ataide J. Bhattacharyya |
spellingShingle |
J. M. Barbosa Filho M. F. Agra R. A. G. Oliveira M. Q. Paulo G. Trolin E. V. L. Cunha J. R. Ataide J. Bhattacharyya Chemical and pharmacological investigation of Solanum species of Brazil: a search for solasodine and other potentially useful therapeutic agents Memórias do Instituto Oswaldo Cruz. soladine steroidal hormones Solanum alkaloid |
author_facet |
J. M. Barbosa Filho M. F. Agra R. A. G. Oliveira M. Q. Paulo G. Trolin E. V. L. Cunha J. R. Ataide J. Bhattacharyya |
author_sort |
J. M. Barbosa Filho |
title |
Chemical and pharmacological investigation of Solanum species of Brazil: a search for solasodine and other potentially useful therapeutic agents |
title_short |
Chemical and pharmacological investigation of Solanum species of Brazil: a search for solasodine and other potentially useful therapeutic agents |
title_full |
Chemical and pharmacological investigation of Solanum species of Brazil: a search for solasodine and other potentially useful therapeutic agents |
title_fullStr |
Chemical and pharmacological investigation of Solanum species of Brazil: a search for solasodine and other potentially useful therapeutic agents |
title_full_unstemmed |
Chemical and pharmacological investigation of Solanum species of Brazil: a search for solasodine and other potentially useful therapeutic agents |
title_sort |
chemical and pharmacological investigation of solanum species of brazil: a search for solasodine and other potentially useful therapeutic agents |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
series |
Memórias do Instituto Oswaldo Cruz. |
issn |
0074-0276 1678-8060 |
publishDate |
1991-01-01 |
description |
A systematic search for solasodine, an important staring material for the partial synthesis of steroidal hormones as well as other potentially bioactive constituents of various Solanum species of Brazil has been undertaken. Thus, the fruits of S. paludosum, S. asperum, S. sessiliforum and Solanum sp. were found to contain significant amounts of solasodine. The root bark of S. paludosum which showe durare like activity yelded tomatidenol and another yet unidentified alkaloid responsible for the biological activity. The fruits of S. asperum yelded a new spirosolane alkaloid, solaparnaine. The stem bark of S. pseudo-quina showed convulsive and exitatory activity from which (25S)-isosolafloridine was identified as the active principle. In addition, the latter alkaloid was also found to show antimicrobial activity. |
topic |
soladine steroidal hormones Solanum alkaloid |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600043 |
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