Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models
Advances in cancer research have shown that a tumor can be likened to a foreign species that disrupts delicately balanced ecological interactions, compromising the survival of normal tissue ecosystems. In efforts to mitigate tumor expansion and metastasis, experimental approaches from ecology are be...
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Frontiers Media S.A.
2015-07-01
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00170/full |
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doaj-651a0b6c1b6145d6b89719b7a7de1ca22020-11-25T00:32:41ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2015-07-01510.3389/fonc.2015.00170141515Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture modelsJiyun eKim0Jiyun eKim1Kandice eTanner2Center for Cancer Research,National Cancer Institute, National Institutes of HealthSeoul National UniversityCenter for Cancer Research,National Cancer Institute, National Institutes of HealthAdvances in cancer research have shown that a tumor can be likened to a foreign species that disrupts delicately balanced ecological interactions, compromising the survival of normal tissue ecosystems. In efforts to mitigate tumor expansion and metastasis, experimental approaches from ecology are becoming more frequently and successfully applied by researchers from diverse disciplines to reverse engineer and re-engineer biological systems in order to normalize the tumor ecosystem. We present a review on the use of 3D biomimetic platforms to recapitulate biotic and abiotic components of the tumor ecosystem, in efforts to delineate the underlying mechanisms that drive evolution of tumor heterogeneity, tumor dissemination and acquisition of drug resistance.http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00170/fullEcologyHydrogelsTumor Microenvironmentbiomaterials and nanotechnology3D culture models |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiyun eKim Jiyun eKim Kandice eTanner |
spellingShingle |
Jiyun eKim Jiyun eKim Kandice eTanner Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models Frontiers in Oncology Ecology Hydrogels Tumor Microenvironment biomaterials and nanotechnology 3D culture models |
author_facet |
Jiyun eKim Jiyun eKim Kandice eTanner |
author_sort |
Jiyun eKim |
title |
Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models |
title_short |
Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models |
title_full |
Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models |
title_fullStr |
Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models |
title_full_unstemmed |
Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models |
title_sort |
recapitulating the tumor ecosystem along the metastatic cascade using 3d culture models |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2015-07-01 |
description |
Advances in cancer research have shown that a tumor can be likened to a foreign species that disrupts delicately balanced ecological interactions, compromising the survival of normal tissue ecosystems. In efforts to mitigate tumor expansion and metastasis, experimental approaches from ecology are becoming more frequently and successfully applied by researchers from diverse disciplines to reverse engineer and re-engineer biological systems in order to normalize the tumor ecosystem. We present a review on the use of 3D biomimetic platforms to recapitulate biotic and abiotic components of the tumor ecosystem, in efforts to delineate the underlying mechanisms that drive evolution of tumor heterogeneity, tumor dissemination and acquisition of drug resistance. |
topic |
Ecology Hydrogels Tumor Microenvironment biomaterials and nanotechnology 3D culture models |
url |
http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00170/full |
work_keys_str_mv |
AT jiyunekim recapitulatingthetumorecosystemalongthemetastaticcascadeusing3dculturemodels AT jiyunekim recapitulatingthetumorecosystemalongthemetastaticcascadeusing3dculturemodels AT kandiceetanner recapitulatingthetumorecosystemalongthemetastaticcascadeusing3dculturemodels |
_version_ |
1725319550709268480 |