Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models

Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models

Advances in cancer research have shown that a tumor can be likened to a foreign species that disrupts delicately balanced ecological interactions, compromising the survival of normal tissue ecosystems. In efforts to mitigate tumor expansion and metastasis, experimental approaches from ecology are be...

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Main Authors: Jiyun eKim, Kandice eTanner
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Oncology
Subjects:
Ecology
Hydrogels
Tumor Microenvironment
biomaterials and nanotechnology
3D culture models
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00170/full
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spelling doaj-651a0b6c1b6145d6b89719b7a7de1ca22020-11-25T00:32:41ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2015-07-01510.3389/fonc.2015.00170141515Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture modelsJiyun eKim0Jiyun eKim1Kandice eTanner2Center for Cancer Research,National Cancer Institute, National Institutes of HealthSeoul National UniversityCenter for Cancer Research,National Cancer Institute, National Institutes of HealthAdvances in cancer research have shown that a tumor can be likened to a foreign species that disrupts delicately balanced ecological interactions, compromising the survival of normal tissue ecosystems. In efforts to mitigate tumor expansion and metastasis, experimental approaches from ecology are becoming more frequently and successfully applied by researchers from diverse disciplines to reverse engineer and re-engineer biological systems in order to normalize the tumor ecosystem. We present a review on the use of 3D biomimetic platforms to recapitulate biotic and abiotic components of the tumor ecosystem, in efforts to delineate the underlying mechanisms that drive evolution of tumor heterogeneity, tumor dissemination and acquisition of drug resistance.http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00170/fullEcologyHydrogelsTumor Microenvironmentbiomaterials and nanotechnology3D culture models
collection DOAJ
language English
format Article
sources DOAJ
author Jiyun eKim
Jiyun eKim
Kandice eTanner
spellingShingle Jiyun eKim
Jiyun eKim
Kandice eTanner
Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models
Frontiers in Oncology
Ecology
Hydrogels
Tumor Microenvironment
biomaterials and nanotechnology
3D culture models
author_facet Jiyun eKim
Jiyun eKim
Kandice eTanner
author_sort Jiyun eKim
title Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models
title_short Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models
title_full Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models
title_fullStr Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models
title_full_unstemmed Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models
title_sort recapitulating the tumor ecosystem along the metastatic cascade using 3d culture models
publisher Frontiers Media S.A.
series Frontiers in Oncology
issn 2234-943X
publishDate 2015-07-01
description Advances in cancer research have shown that a tumor can be likened to a foreign species that disrupts delicately balanced ecological interactions, compromising the survival of normal tissue ecosystems. In efforts to mitigate tumor expansion and metastasis, experimental approaches from ecology are becoming more frequently and successfully applied by researchers from diverse disciplines to reverse engineer and re-engineer biological systems in order to normalize the tumor ecosystem. We present a review on the use of 3D biomimetic platforms to recapitulate biotic and abiotic components of the tumor ecosystem, in efforts to delineate the underlying mechanisms that drive evolution of tumor heterogeneity, tumor dissemination and acquisition of drug resistance.
topic Ecology
Hydrogels
Tumor Microenvironment
biomaterials and nanotechnology
3D culture models
url http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00170/full
work_keys_str_mv AT jiyunekim recapitulatingthetumorecosystemalongthemetastaticcascadeusing3dculturemodels
AT jiyunekim recapitulatingthetumorecosystemalongthemetastaticcascadeusing3dculturemodels
AT kandiceetanner recapitulatingthetumorecosystemalongthemetastaticcascadeusing3dculturemodels
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