Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive Women
It has been previously documented that carotid intima-media thickness (cIMT) is a predictor of cardiovascular disease. The aim of this study was to identify clinical parameters associated with an increased cIMT treated hypertensive women. Female patients (n=116) with essential hypertension, aged 40–...
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doaj-6522f03bb96e4f2aa286966b333f3df32020-11-25T00:30:58ZengHindawi LimitedInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/257501257501Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive WomenMichelle Trindade0Renata Brum Martucci1Adriana K. Burlá2Wille Oigman3Mario Fritsch Neves4Denizar Vianna Araújo5Department of Clinical Medicine, State University of Rio de Janeiro, Rua Vinte e Oito de Setembro, 77, Sala 329—Vila Isabel, 20551-030—Rio de Janeiro, RJ, BrazilInstitution of Nutrition, State University of Rio de Janeiro, Rua Vinte e Oito de Setembro, 77, Sala 329, Vila Isabel, 20551-030 Rio de Janeiro, RJ, BrazilDepartment of Clinical Medicine, State University of Rio de Janeiro, Rua Vinte e Oito de Setembro, 77, Sala 329—Vila Isabel, 20551-030—Rio de Janeiro, RJ, BrazilDepartment of Clinical Medicine, State University of Rio de Janeiro, Rua Vinte e Oito de Setembro, 77, Sala 329—Vila Isabel, 20551-030—Rio de Janeiro, RJ, BrazilDepartment of Clinical Medicine, State University of Rio de Janeiro, Rua Vinte e Oito de Setembro, 77, Sala 329—Vila Isabel, 20551-030—Rio de Janeiro, RJ, BrazilDepartment of Clinical Medicine, State University of Rio de Janeiro, Rua Vinte e Oito de Setembro, 77, Sala 329—Vila Isabel, 20551-030—Rio de Janeiro, RJ, BrazilIt has been previously documented that carotid intima-media thickness (cIMT) is a predictor of cardiovascular disease. The aim of this study was to identify clinical parameters associated with an increased cIMT treated hypertensive women. Female patients (n=116) with essential hypertension, aged 40–65 years, were included in this study. Vascular ultrasound was performed and the patients were divided into two groups according to the values of cIMT (< or ≥0.9 mm). Patients with greater cIMT presented significantly higher systolic blood pressure and pulse pressure. Serum HDL-cholesterol was significantly lower and CRP was significantly higher in the same group. There was a significant correlation between cIMT and age (r=0.25, P=0.007), systolic blood pressure (r=0.19, P=0.009), pulse pressure (r=0.30, P=0.001), and LDL-cholesterol (r=0.19, P=0.043). cIMT was correlated to CRP (r=0.31, P=0.007) and negatively correlated to HDL-cholesterol (r=0.33, P=0.001). In logistic regression, only HDL-cholesterol, CRP, and pulse pressure were shown to be independent variables associated to increased cIMT. In conclusion, pulse pressure, HDL-cholesterol, and CRP are variables correlated with cIMT in treated hypertensive women.http://dx.doi.org/10.1155/2012/257501 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michelle Trindade Renata Brum Martucci Adriana K. Burlá Wille Oigman Mario Fritsch Neves Denizar Vianna Araújo |
spellingShingle |
Michelle Trindade Renata Brum Martucci Adriana K. Burlá Wille Oigman Mario Fritsch Neves Denizar Vianna Araújo Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive Women International Journal of Hypertension |
author_facet |
Michelle Trindade Renata Brum Martucci Adriana K. Burlá Wille Oigman Mario Fritsch Neves Denizar Vianna Araújo |
author_sort |
Michelle Trindade |
title |
Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive Women |
title_short |
Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive Women |
title_full |
Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive Women |
title_fullStr |
Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive Women |
title_full_unstemmed |
Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive Women |
title_sort |
evaluation of clinical variables associated with increased carotid intima-media thickness in middle-aged hypertensive women |
publisher |
Hindawi Limited |
series |
International Journal of Hypertension |
issn |
2090-0384 2090-0392 |
publishDate |
2012-01-01 |
description |
It has been previously documented that carotid intima-media thickness (cIMT) is a predictor of cardiovascular disease. The aim of this study was to identify clinical parameters associated with an increased cIMT treated hypertensive women. Female patients (n=116) with essential hypertension, aged 40–65 years, were included in this study. Vascular ultrasound was performed and the patients were divided into two groups according to the values of cIMT (< or ≥0.9 mm). Patients with greater cIMT presented significantly higher systolic blood pressure and pulse pressure. Serum HDL-cholesterol was significantly lower and CRP was significantly higher in the same group. There was a significant correlation between cIMT and age (r=0.25, P=0.007), systolic blood pressure (r=0.19, P=0.009), pulse pressure (r=0.30, P=0.001), and LDL-cholesterol (r=0.19, P=0.043). cIMT was correlated to CRP (r=0.31, P=0.007) and negatively correlated to HDL-cholesterol (r=0.33, P=0.001). In logistic regression, only HDL-cholesterol, CRP, and pulse pressure were shown to be independent variables associated to increased cIMT. In conclusion, pulse pressure, HDL-cholesterol, and CRP are variables correlated with cIMT in treated hypertensive women. |
url |
http://dx.doi.org/10.1155/2012/257501 |
work_keys_str_mv |
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