Polymorphic SERPINA3 prolongs oligomeric state of amyloid beta.
Molecular chaperon SERPINA3 colocalizes with accumulated amyloid peptide in Alzheimer's disease (AD) patient's brain. From the QTL analysis, we narrowed down Serpina3 with two SNPs in senescence-accelerated mouse prone (SAMP) 8 strain. Our study showed SAMP8 type Serpina3 prolonged retenti...
Main Authors: | Maruf Mohammad Akbor, Nobuyuki Kurosawa, Hiroki Nakayama, Ayumi Nakatani, Koji Tomobe, Yoichi Chiba, Masaki Ueno, Masashi Tanaka, Yasuyuki Nomura, Masaharu Isobe |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0248027 |
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