Effect of rhubarb on extravascular lung water in patients with acute respiratory distress syndrome

Summary Objective: The aim of this study was to evaluate the effect of rhubarb on extravascular lung water (EVLW) in patients with acute respiratory distress syndrome (ARDS). Method: A total of 80 patients with ARDS were randomly divided into a treatment group (40 cases) and control group (40 case...

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Main Authors: Jianxin He, Xiaoshui Si, Mingxia Ji, Jing Huang, Wenjuan Zheng, Jiao Wang, Junfeng Wang, Lijun Zhu
Format: Article
Language:English
Published: Associação Médica Brasileira
Series:Revista da Associação Médica Brasileira
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000500435&lng=en&tlng=en
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spelling doaj-6532d879d1124c63b8258fa0207181c62020-11-24T22:52:14ZengAssociação Médica BrasileiraRevista da Associação Médica Brasileira1806-928263543544010.1590/1806-9282.63.05.435S0104-42302017000500435Effect of rhubarb on extravascular lung water in patients with acute respiratory distress syndromeJianxin HeXiaoshui SiMingxia JiJing HuangWenjuan ZhengJiao WangJunfeng WangLijun ZhuSummary Objective: The aim of this study was to evaluate the effect of rhubarb on extravascular lung water (EVLW) in patients with acute respiratory distress syndrome (ARDS). Method: A total of 80 patients with ARDS were randomly divided into a treatment group (40 cases) and control group (40 cases). Patients in the treatment group received rhubarb (30.0 g/d) and patients in the control group received conventional therapy for seven consecutive days. Extravascular lung water index (EVLWI) and pulmonary vascular permeability index (PVPI) were determined using pulse contour cardiac output (PiCCO) technology, and the oxygenation index was measured by blood gas analysis at baseline and on days 3, 5 and 7 after treatment. Results: The oxygenation index was higher and the levels of EVLWI and PVPI were lower after treatment in the two groups; however, these indexes showed significant differences on the 5th and 7th days after rhubarb treatment compared with the results in the control group (p<0.05). Conclusion: Rhubarb can decrease EVLWI and PVPI, and improve oxygenation in patients with ARDS.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000500435&lng=en&tlng=enrhubarbARDSEVLWIoxygenation index
collection DOAJ
language English
format Article
sources DOAJ
author Jianxin He
Xiaoshui Si
Mingxia Ji
Jing Huang
Wenjuan Zheng
Jiao Wang
Junfeng Wang
Lijun Zhu
spellingShingle Jianxin He
Xiaoshui Si
Mingxia Ji
Jing Huang
Wenjuan Zheng
Jiao Wang
Junfeng Wang
Lijun Zhu
Effect of rhubarb on extravascular lung water in patients with acute respiratory distress syndrome
Revista da Associação Médica Brasileira
rhubarb
ARDS
EVLWI
oxygenation index
author_facet Jianxin He
Xiaoshui Si
Mingxia Ji
Jing Huang
Wenjuan Zheng
Jiao Wang
Junfeng Wang
Lijun Zhu
author_sort Jianxin He
title Effect of rhubarb on extravascular lung water in patients with acute respiratory distress syndrome
title_short Effect of rhubarb on extravascular lung water in patients with acute respiratory distress syndrome
title_full Effect of rhubarb on extravascular lung water in patients with acute respiratory distress syndrome
title_fullStr Effect of rhubarb on extravascular lung water in patients with acute respiratory distress syndrome
title_full_unstemmed Effect of rhubarb on extravascular lung water in patients with acute respiratory distress syndrome
title_sort effect of rhubarb on extravascular lung water in patients with acute respiratory distress syndrome
publisher Associação Médica Brasileira
series Revista da Associação Médica Brasileira
issn 1806-9282
description Summary Objective: The aim of this study was to evaluate the effect of rhubarb on extravascular lung water (EVLW) in patients with acute respiratory distress syndrome (ARDS). Method: A total of 80 patients with ARDS were randomly divided into a treatment group (40 cases) and control group (40 cases). Patients in the treatment group received rhubarb (30.0 g/d) and patients in the control group received conventional therapy for seven consecutive days. Extravascular lung water index (EVLWI) and pulmonary vascular permeability index (PVPI) were determined using pulse contour cardiac output (PiCCO) technology, and the oxygenation index was measured by blood gas analysis at baseline and on days 3, 5 and 7 after treatment. Results: The oxygenation index was higher and the levels of EVLWI and PVPI were lower after treatment in the two groups; however, these indexes showed significant differences on the 5th and 7th days after rhubarb treatment compared with the results in the control group (p<0.05). Conclusion: Rhubarb can decrease EVLWI and PVPI, and improve oxygenation in patients with ARDS.
topic rhubarb
ARDS
EVLWI
oxygenation index
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000500435&lng=en&tlng=en
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