Breviscapine Pretreatment Inhibits Myocardial Inflammation and Apoptosis in Rats After Coronary Microembolization by Activating the PI3K/Akt/GSK-3β Signaling Pathway

Breviscapine Pretreatment Inhibits Myocardial Inflammation and Apoptosis in Rats After Coronary Microembolization by Activating the PI3K/Akt/GSK-3β Signaling Pathway

Zhi-Qing Chen,1 You Zhou,1 Feng Chen,2 Jun-Wen Huang,1 Jing Zheng,1 Hao-Liang Li,1 Tao Li,1 Lang Li1 1Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University & Guangxi Key Laboratory Base of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Preve...

Full description

Bibliographic Details
Main Authors:	Chen ZQ, Zhou Y, Chen F, Huang JW, Zheng J, Li HL, Li T, Li L
Format:	Article
Language:	English
Published:	Dove Medical Press 2021-02-01
Series:	Drug Design, Development and Therapy
Subjects:	breviscapine coronary microembolization pi3k/akt/gsk-3β myocardial inflammation apoptosis
Online Access:	https://www.dovepress.com/breviscapine-pretreatment-inhibits-myocardial-inflammation-and-apoptos-peer-reviewed-article-DDDT

Similar Items

Resveratrol Pretreatment Inhibits Myocardial Apoptosis in Rats Following Coronary Microembolization via Inducing the PI3K/Akt/GSK-3β Signaling Cascade
by: Li T, et al.
Published: (2021-09-01)

Breviscapine suppresses the growth and metastasis of prostate cancer through regulating PAQR4-mediated PI3K/Akt pathway
by: Jiwei Ye, et al.
Published: (2020-07-01)

Atorvastatin Inhibits Myocardial Apoptosis in a Swine Model of Coronary Microembolization by Regulating PTEN/PI3K/Akt Signaling Pathway
by: Jiangyou Wang, et al.
Published: (2016-01-01)

Levosimendan Pretreatment Inhibits Myocardial Apoptosis in Swine after Coronary Microembolization
by: Lang Li, et al.
Published: (2017-01-01)

Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses
by: Satoru Matsuda, et al.
Published: (2019-02-01)

Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia by regulating the PI3K/Akt/GSK-3β signaling pathway
by: Qing Yang, et al.
Published: (2019-02-01)

Alprostadil Injection Attenuates Coronary Microembolization-Induced Myocardial Injury Through GSK-3β/Nrf2/HO-1 Signaling-Mediated Apoptosis Inhibition
by: Qin Z, et al.
Published: (2020-10-01)

Cryptotanshinone Induces Cell Cycle Arrest and Apoptosis of NSCLC Cells through the PI3K/Akt/GSK-3β Pathway
by: Sang-A Kim, et al.
Published: (2018-09-01)

Shikonin Attenuates Acetaminophen-Induced Hepatotoxicity by Upregulation of Nrf2 through Akt/GSK3β Signaling
by: Huachao Li, et al.
Published: (2018-12-01)

Isoquercitrin Inhibits Hydrogen Peroxide-Induced Apoptosis of EA.hy926 Cells via the PI3K/Akt/GSK3β Signaling Pathway
by: Meixia Zhu, et al.
Published: (2016-03-01)

Treatment With Liraglutide Exerts Neuroprotection After Hypoxic–Ischemic Brain Injury in Neonatal Rats via the PI3K/AKT/GSK3β Pathway
by: Shan-shan Zeng, et al.
Published: (2020-01-01)

Elevated Expression of Zinc Finger Protein 703 Promotes Cell Proliferation and Metastasis through PI3K/AKT/GSK-3β Signalling in Oral Squamous Cell Carcinoma
by: Hao Wang, et al.
Published: (2017-11-01)

Neuroprotective Effects of Salicin in a Gerbil Model of Transient Forebrain Ischemia by Attenuating Oxidative Stress and Activating PI3K/Akt/GSK3β Pathway
by: Joon Ha Park, et al.
Published: (2021-04-01)

AKT/GSK3 signaling pathways and schizophrenia
by: Effat eEmamian
Published: (2012-03-01)

Neuroprotective potential of ketamine prevents developing brain structure impairment and alteration of neurocognitive function induced via isoflurane through the PI3K/AKT/GSK-3β pathway
by: Wang R, et al.
Published: (2019-02-01)

Phosphorylated peptides from Antarctic krill (Euphausia superba) ameliorated osteoporosis by activation of osteogenesis-related MAPKs and PI3K/AKT/GSK-3β pathways in dexamethasone-treated mice
by: Lihua Han, et al.
Published: (2018-08-01)

Paeoniflorin Inhibits Mesangial Cell Proliferation and Inflammatory Response in Rats With Mesangial Proliferative Glomerulonephritis Through PI3K/AKT/GSK-3β Pathway
by: Bihao Liu, et al.
Published: (2019-09-01)

SHP2 promotes proliferation of breast cancer cells through regulating Cyclin D1 stability via the PI3K/AKT/GSK3β signaling pathway
by: Yue Yuan*, et al.
Published: (2020-08-01)

Protective Effect of Minocycline against Ketamine-induced Injury in Neural Stem Cell: Involvement of PI3K/Akt and Gsk-3 beta Pathway
by: Yang Lu, et al.
Published: (2016-12-01)

ARHGAP10 inhibits the epithelial–mesenchymal transition of non-small cell lung cancer by inactivating PI3K/Akt/GSK3β signaling pathway
by: Lan-Lan Lin, et al.
Published: (2021-06-01)

Sevoflurane pretreatment attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis through activation of AKT/pim-1 and AKT/GSK3β signaling pathways
by: Wensheng Zhao, et al.
Published: (2019-01-01)

Hydrogen-Rich Saline Attenuates Brain Injury Induced by Cardiopulmonary Bypass and Inhibits Microvascular Endothelial Cell Apoptosis Via the PI3K/Akt/GSK3β Signaling Pathway in Rats
by: Keyan Chen, et al.
Published: (2017-10-01)

CK2α Regulates the Metastases and Migration of Lung Adenocarcinoma  A549 Cell Line through PI3K/Akt/GSK-3β Signal Pathway
by: Aibing WU, et al.
Published: (2017-04-01)

Erinacine Facilitates the Opening of the Mitochondrial Permeability Transition Pore Through the Inhibition of the PI3K/ Akt/GSK-3β Signaling Pathway in Human Hepatocellular Carcinoma
by: Li-Jie Zhou, et al.
Published: (2018-10-01)

Resveratrol modulates the Akt/GSK-3β signaling pathway in a middle cerebral artery occlusion animal model
by: Dong-Ju Park, et al.
Published: (2019-10-01)

“Olfactory three-needle” acupuncture enhances synaptic function in A𝜷1-42-induced Alzheimer’s disease via activating PI3K/AKT/GSK-3𝜷 signaling pathway
by: Yuan Wang, et al.
Published: (2021-03-01)

Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review
by: Jialiang Gao, et al.
Published: (2017-05-01)

Protective effects of paeonol on cardiovascular complications in diabetes mellitus involves modulation of PI3K /Akt-GSK-3β signalling, regulation of protease-activated receptor-1 expressions and down-regulation of inflammatory mediators
by: Jun Li, et al.
Published: (2015-11-01)

Improving Breviscapine Oral Bioavailability by Preparing Nanosuspensions, Liposomes and Phospholipid Complexes
by: Zilin Song, et al.
Published: (2021-01-01)

Emodin Protects against Diabetic Cardiomyopathy by Regulating the AKT/GSK-3β Signaling Pathway in the Rat Model
by: Zhiqin Wu, et al.
Published: (2014-09-01)

The Role of Insulin/IGF-1/PI3K/Akt/GSK3β Signaling in Parkinson's Disease Dementia
by: Liying Yang, et al.
Published: (2018-02-01)

Mechanisms of Host-Defense Against Intracellular Bacterial Pathogens Through The PI3K/Akt Host Signaling Pathway
by: Cremer, Thomas John, IV
Published: (2010)

Acute Ethanol inhibition of γ Oscillations is mediated by Akt and GSK-3β
by: JianGang Wang, et al.
Published: (2016-08-01)

Pharmacological evidence for lithium-induced neuroprotection against methamphetamine-induced neurodegeneration via Akt-1/GSK3 and CREB-BDNF signaling pathways
by: Shafagh Mehrafza, et al.
Published: (2019-08-01)

Puerarin attenuates locomotor and cognitive deficits as well as hippocampal neuronal injury through the PI3K/Akt1/GSK-3 beta signaling pathway in an in vivo model of cerebral ischemia
by: Tao, Jinhao, et al.
Published: (2017)

MicroRNA-126 enhances the biological function of endothelial progenitor cells under oxidative stress via PI3K/Akt/GSK-3β and ERK1/2 signaling pathways
by: Qinqin Wu, et al.
Published: (2020-01-01)

TMEM17 promotes malignant progression of breast cancer via AKT/GSK3β signaling
by: Zhao Y, et al.
Published: (2018-08-01)

Protective effects of medicinal plant breviscapine on postcerebral hemorrhage in rats
by: Zupeng Chen, Cheng Wang, Yajun Liu, Xiaolong Liang, Chao Yang, Xin Zhang, Xu Li
Published: (2020-03-01)

Neuroprotection Against Parkinson’s Disease Through the Activation of Akt/GSK3β Signaling Pathway by Tovophyllin A
by: Yanjun Huang, et al.
Published: (2020-07-01)

Akt2 Deficiency is Associated with Anxiety and Depressive Behavior in Mice
by: Christina Leibrock, et al.
Published: (2013-09-01)