Effects of emergency hyperbaric oxygen therapy on nerve injury, angiogenesis and cerebral blood perfusion in patients with acute cerebral infarction
Objective: To explore the effects of emergency hyperbaric oxygen therapy on nerve injury, angiogenesis and cerebral blood perfusion in patients with acute cerebral infarction. Methods: A total of 118 patients with acute cerebral infarction who were treated in the hospital between April 2015 and O...
Main Author: | |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2018-07-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201814/12.pdf |
Summary: | Objective: To explore the effects of emergency hyperbaric oxygen therapy on nerve injury,
angiogenesis and cerebral blood perfusion in patients with acute cerebral infarction. Methods:
A total of 118 patients with acute cerebral infarction who were treated in the hospital between
April 2015 and October 2017 were selected as study subjects and divided into hyperbaric
oxygen group (n=59) and control group (n=59) by random number table method. Control
group received conventional therapy, hyperbaric oxygen group received conventional therapy
combined with hyperbaric oxygen therapy, and both groups were treated for 2 weeks. The
differences in nerve injury, angiogenesis and cerebral blood perfusion were compared between
the two groups before and after treatment. Results: Differences in nerve injury, angiogenesis
and cerebral perfusion were not significant between the two groups immediately after
diagnosis. After 2 weeks of treatment, serum nerve injury indexes IGF-1, Copeptin, PAO,
AQP4 and H-FABP contents of hyperbaric oxygen group were lower than those of control
group; serum angiogenesis indexes PEDF, Ang-1 and VEGF contents were higher than those of
control group whereas ES content was lower than that of control group; stenotic-side cerebral
blood perfusion parameters CBF and CBV levels were higher than those of control group
whereas TTP level was lower than that of control group. Conclusion: Emergency hyperbaric
oxygen therapy can effectively reduce nerve injury, promote cerebral angiogenesis and increase
cerebral blood perfusion in patients with acute cerebral infarction. |
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ISSN: | 1007-1237 1007-1237 |