The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection
Human neurodegenerative diseases are accompanied by accumulation of heavily oxidized and aggregated proteins. However, the exact molecular reason is not fully elucidated yet. Insufficient cellular protein quality control is thought to play an important role in accumulating covalently oxidized misfol...
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doaj-6568d4597e3d48ae87aed74c906be3b52020-11-24T22:49:01ZengMDPI AGMolecules1420-30492017-01-0122115910.3390/molecules22010159molecules22010159The Effect of Polyphenols on Protein Degradation Pathways: Implications for NeuroprotectionParvana Hajieva0Department of Pathobiochemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55099 Mainz, GermanyHuman neurodegenerative diseases are accompanied by accumulation of heavily oxidized and aggregated proteins. However, the exact molecular reason is not fully elucidated yet. Insufficient cellular protein quality control is thought to play an important role in accumulating covalently oxidized misfolded proteins. Pharmacologically active polyphenols and their derivatives exhibit potential for preventive and therapeutic purposes against protein aggregation during neurodegeneration. Although these compounds act on various biochemical pathways, their role in stabilizing the protein degradation machinery at different stages may be an attractive therapeutical strategy to halt the accumulation of misfolded proteins. This review evaluates and discusses the existing scientific literature on the effect of polyphenols on three major protein degradation pathways: chaperone-mediated autophagy, the proteasome and macroautophagy. The results of these studies demonstrate that phenolic compounds are able to influence the major protein degradation pathways at different levels.http://www.mdpi.com/1420-3049/22/1/159protein oxidationproteostasisprotein degradationproteasomemacroautophagychaperone-mediated autophagyneuroprotection |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Parvana Hajieva |
spellingShingle |
Parvana Hajieva The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection Molecules protein oxidation proteostasis protein degradation proteasome macroautophagy chaperone-mediated autophagy neuroprotection |
author_facet |
Parvana Hajieva |
author_sort |
Parvana Hajieva |
title |
The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection |
title_short |
The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection |
title_full |
The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection |
title_fullStr |
The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection |
title_full_unstemmed |
The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection |
title_sort |
effect of polyphenols on protein degradation pathways: implications for neuroprotection |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2017-01-01 |
description |
Human neurodegenerative diseases are accompanied by accumulation of heavily oxidized and aggregated proteins. However, the exact molecular reason is not fully elucidated yet. Insufficient cellular protein quality control is thought to play an important role in accumulating covalently oxidized misfolded proteins. Pharmacologically active polyphenols and their derivatives exhibit potential for preventive and therapeutic purposes against protein aggregation during neurodegeneration. Although these compounds act on various biochemical pathways, their role in stabilizing the protein degradation machinery at different stages may be an attractive therapeutical strategy to halt the accumulation of misfolded proteins. This review evaluates and discusses the existing scientific literature on the effect of polyphenols on three major protein degradation pathways: chaperone-mediated autophagy, the proteasome and macroautophagy. The results of these studies demonstrate that phenolic compounds are able to influence the major protein degradation pathways at different levels. |
topic |
protein oxidation proteostasis protein degradation proteasome macroautophagy chaperone-mediated autophagy neuroprotection |
url |
http://www.mdpi.com/1420-3049/22/1/159 |
work_keys_str_mv |
AT parvanahajieva theeffectofpolyphenolsonproteindegradationpathwaysimplicationsforneuroprotection AT parvanahajieva effectofpolyphenolsonproteindegradationpathwaysimplicationsforneuroprotection |
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1725677558232514560 |