Effects of Statins on Renin–Angiotensin System

Effects of Statins on Renin–Angiotensin System

Statins, a class of drugs for lowering serum LDL-cholesterol, have attracted attention because of their wide range of pleiotropic effects. An important but often neglected effect of statins is their role in the renin–angiotensin system (RAS) pathway. This pathway plays an integral role in the progre...

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Main Authors: Nasim Kiaie, Armita Mahdavi Gorabi, Željko Reiner, Tannaz Jamialahmadi, Massimiliano Ruscica, Amirhossein Sahebkar
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
statins
renin–angiotensin system (RAS)
hypertension
Online Access:https://www.mdpi.com/2308-3425/8/7/80
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spelling doaj-657c39d3c013490993d90ffc8885ab362021-07-23T13:47:41ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252021-07-018808010.3390/jcdd8070080Effects of Statins on Renin–Angiotensin SystemNasim Kiaie0Armita Mahdavi Gorabi1Željko Reiner2Tannaz Jamialahmadi3Massimiliano Ruscica4Amirhossein Sahebkar5Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, IranResearch Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, IranDepartment of Internal Diseases, School of Medicine, University Hospital Center Zagreb, Zagreb University, 10000 Zagreb, CroatiaQuchan Branch, Department of Food Science and Technology, Islamic Azad University, Quchan 9479176135, IranDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, ItalyBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 9177948564, IranStatins, a class of drugs for lowering serum LDL-cholesterol, have attracted attention because of their wide range of pleiotropic effects. An important but often neglected effect of statins is their role in the renin–angiotensin system (RAS) pathway. This pathway plays an integral role in the progression of several diseases including hypertension, heart failure, and renal disease. In this paper, the role of statins in the blockade of different components of this pathway and the underlying mechanisms are reviewed and new therapeutic possibilities of statins are suggested.https://www.mdpi.com/2308-3425/8/7/80statinsrenin–angiotensin system (RAS)hypertension
collection DOAJ
language English
format Article
sources DOAJ
author Nasim Kiaie
Armita Mahdavi Gorabi
Željko Reiner
Tannaz Jamialahmadi
Massimiliano Ruscica
Amirhossein Sahebkar
spellingShingle Nasim Kiaie
Armita Mahdavi Gorabi
Željko Reiner
Tannaz Jamialahmadi
Massimiliano Ruscica
Amirhossein Sahebkar
Effects of Statins on Renin–Angiotensin System
Journal of Cardiovascular Development and Disease
statins
renin–angiotensin system (RAS)
hypertension
author_facet Nasim Kiaie
Armita Mahdavi Gorabi
Željko Reiner
Tannaz Jamialahmadi
Massimiliano Ruscica
Amirhossein Sahebkar
author_sort Nasim Kiaie
title Effects of Statins on Renin–Angiotensin System
title_short Effects of Statins on Renin–Angiotensin System
title_full Effects of Statins on Renin–Angiotensin System
title_fullStr Effects of Statins on Renin–Angiotensin System
title_full_unstemmed Effects of Statins on Renin–Angiotensin System
title_sort effects of statins on renin–angiotensin system
publisher MDPI AG
series Journal of Cardiovascular Development and Disease
issn 2308-3425
publishDate 2021-07-01
description Statins, a class of drugs for lowering serum LDL-cholesterol, have attracted attention because of their wide range of pleiotropic effects. An important but often neglected effect of statins is their role in the renin–angiotensin system (RAS) pathway. This pathway plays an integral role in the progression of several diseases including hypertension, heart failure, and renal disease. In this paper, the role of statins in the blockade of different components of this pathway and the underlying mechanisms are reviewed and new therapeutic possibilities of statins are suggested.
topic statins
renin–angiotensin system (RAS)
hypertension
url https://www.mdpi.com/2308-3425/8/7/80
work_keys_str_mv AT nasimkiaie effectsofstatinsonreninangiotensinsystem
AT armitamahdavigorabi effectsofstatinsonreninangiotensinsystem
AT zeljkoreiner effectsofstatinsonreninangiotensinsystem
AT tannazjamialahmadi effectsofstatinsonreninangiotensinsystem
AT massimilianoruscica effectsofstatinsonreninangiotensinsystem
AT amirhosseinsahebkar effectsofstatinsonreninangiotensinsystem
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