Genetic Variants Involved in One-Carbon Metabolism: Polymorphism Frequencies and Differences in Homocysteine Concentrations in the Folic Acid Fortification Era
Folate and other B vitamins are essential co-factors of one-carbon metabolism, and genetic variants, such as polymorphisms, can alter the metabolism. Furthermore, the adoption of food fortification with folic acid showed a decrease of homocysteine concentration. The aim of this study was to investig...
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doaj-657d7bbabe354510a8dc1ccccfb7c9a42020-11-24T23:58:13ZengMDPI AGNutrients2072-66432017-05-019653910.3390/nu9060539nu9060539Genetic Variants Involved in One-Carbon Metabolism: Polymorphism Frequencies and Differences in Homocysteine Concentrations in the Folic Acid Fortification EraJosiane Steluti0Aline M. Carvalho1Antonio A. F. Carioca2Andreia Miranda3Gilka J. F. Gattás4Regina M. Fisberg5Dirce M. Marchioni6Department of Nutrition, School of Public Health, Sao Paulo University, Avenida Doutor Arnaldo, 715-Cerqueira César, São Paulo—SP, São Paulo 01246-904, BrazilDepartment of Nutrition, School of Public Health, Sao Paulo University, Avenida Doutor Arnaldo, 715-Cerqueira César, São Paulo—SP, São Paulo 01246-904, BrazilDepartment of Nutrition, School of Public Health, Sao Paulo University, Avenida Doutor Arnaldo, 715-Cerqueira César, São Paulo—SP, São Paulo 01246-904, BrazilDepartment of Nutrition, School of Public Health, Sao Paulo University, Avenida Doutor Arnaldo, 715-Cerqueira César, São Paulo—SP, São Paulo 01246-904, BrazilDepartment of Legal Medicine, Bioethics and Occupational Health, School of Medicine, University of São Paulo, Avenida Doutor Arnaldo, 455-Cerqueira César, São Paulo—SP, São Paulo 01246-903, BrazilDepartment of Nutrition, School of Public Health, Sao Paulo University, Avenida Doutor Arnaldo, 715-Cerqueira César, São Paulo—SP, São Paulo 01246-904, BrazilDepartment of Nutrition, School of Public Health, Sao Paulo University, Avenida Doutor Arnaldo, 715-Cerqueira César, São Paulo—SP, São Paulo 01246-904, BrazilFolate and other B vitamins are essential co-factors of one-carbon metabolism, and genetic variants, such as polymorphisms, can alter the metabolism. Furthermore, the adoption of food fortification with folic acid showed a decrease of homocysteine concentration. The aim of this study was to investigate the frequencies of the polymorphisms of enzymes and carrier proteins involved in one-carbon metabolism, and to evaluate homocysteine concentrations in the presence of these genetic variants in a population exposed to mandatory food fortification with folic acid. Using data from a population-based cross-sectional study in São Paulo, Brazil, the study population comprised 750 participants above 12 years of age of both genders. A linear regression model was used to evaluate the homocysteine concentrations according to genetic variants and folate level. The results showed that the minor allelic frequencies were 0.33 for MTHFR (rs1801133), 0.24 for MTHFR (rs1801131), 0.19 for MTR (rs1805087), 0.42 for MTRR (rs1801394), 0.46 for RFC1 (rs1051266), and 0.47 for DHFR (19-bp deletion). The genetic variants of MTHFR 677C>T, MTRR 66A>G and RFC-1 80G>A were different according to race. The homocysteine concentrations increased in the CT and TT compared to CC genotypes of polymorphism MTHFR 677C>T in all populations, and differences between the homocysteine concentrations according to the genotypes of MTHFR 677C>T were observed regardless of folate level.http://www.mdpi.com/2072-6643/9/6/539one-carbon metabolismfolic acid fortificationgenetic variantshomocysteinepolymorphisms |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Josiane Steluti Aline M. Carvalho Antonio A. F. Carioca Andreia Miranda Gilka J. F. Gattás Regina M. Fisberg Dirce M. Marchioni |
spellingShingle |
Josiane Steluti Aline M. Carvalho Antonio A. F. Carioca Andreia Miranda Gilka J. F. Gattás Regina M. Fisberg Dirce M. Marchioni Genetic Variants Involved in One-Carbon Metabolism: Polymorphism Frequencies and Differences in Homocysteine Concentrations in the Folic Acid Fortification Era Nutrients one-carbon metabolism folic acid fortification genetic variants homocysteine polymorphisms |
author_facet |
Josiane Steluti Aline M. Carvalho Antonio A. F. Carioca Andreia Miranda Gilka J. F. Gattás Regina M. Fisberg Dirce M. Marchioni |
author_sort |
Josiane Steluti |
title |
Genetic Variants Involved in One-Carbon Metabolism: Polymorphism Frequencies and Differences in Homocysteine Concentrations in the Folic Acid Fortification Era |
title_short |
Genetic Variants Involved in One-Carbon Metabolism: Polymorphism Frequencies and Differences in Homocysteine Concentrations in the Folic Acid Fortification Era |
title_full |
Genetic Variants Involved in One-Carbon Metabolism: Polymorphism Frequencies and Differences in Homocysteine Concentrations in the Folic Acid Fortification Era |
title_fullStr |
Genetic Variants Involved in One-Carbon Metabolism: Polymorphism Frequencies and Differences in Homocysteine Concentrations in the Folic Acid Fortification Era |
title_full_unstemmed |
Genetic Variants Involved in One-Carbon Metabolism: Polymorphism Frequencies and Differences in Homocysteine Concentrations in the Folic Acid Fortification Era |
title_sort |
genetic variants involved in one-carbon metabolism: polymorphism frequencies and differences in homocysteine concentrations in the folic acid fortification era |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2017-05-01 |
description |
Folate and other B vitamins are essential co-factors of one-carbon metabolism, and genetic variants, such as polymorphisms, can alter the metabolism. Furthermore, the adoption of food fortification with folic acid showed a decrease of homocysteine concentration. The aim of this study was to investigate the frequencies of the polymorphisms of enzymes and carrier proteins involved in one-carbon metabolism, and to evaluate homocysteine concentrations in the presence of these genetic variants in a population exposed to mandatory food fortification with folic acid. Using data from a population-based cross-sectional study in São Paulo, Brazil, the study population comprised 750 participants above 12 years of age of both genders. A linear regression model was used to evaluate the homocysteine concentrations according to genetic variants and folate level. The results showed that the minor allelic frequencies were 0.33 for MTHFR (rs1801133), 0.24 for MTHFR (rs1801131), 0.19 for MTR (rs1805087), 0.42 for MTRR (rs1801394), 0.46 for RFC1 (rs1051266), and 0.47 for DHFR (19-bp deletion). The genetic variants of MTHFR 677C>T, MTRR 66A>G and RFC-1 80G>A were different according to race. The homocysteine concentrations increased in the CT and TT compared to CC genotypes of polymorphism MTHFR 677C>T in all populations, and differences between the homocysteine concentrations according to the genotypes of MTHFR 677C>T were observed regardless of folate level. |
topic |
one-carbon metabolism folic acid fortification genetic variants homocysteine polymorphisms |
url |
http://www.mdpi.com/2072-6643/9/6/539 |
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