Cholic Acid Stimulates MMP-9 in Human Colon Cancer Cells via Activation of MAPK, AP-1, and NF-κB Activity

Cholic Acid Stimulates MMP-9 in Human Colon Cancer Cells via Activation of MAPK, AP-1, and NF-κB Activity

Matrix metalloproteinase-9 (MMP-9) plays a crucial role in cell invasion and cancer metastasis. In this study, we showed that cholic acid (CA), a major primary bile acid, can induce MMP-9 expression in colon cancer HT29 and SW620 cells. CA increased reactive oxygen species (ROS) production and also...

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Bibliographic Details
Main Authors: Shinan Li, Trong Thuan Ung, Thi Thinh Nguyen, Dhiraj Kumar Sah, Seon Young Park, Young Do Jung
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
cholic acid
matrix metalloproteinase-9
reactive oxygen species
AP-1
NF-κB
MAPK
Online Access:https://www.mdpi.com/1422-0067/21/10/3420

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