Platform comparison for evaluation of ALK protein immunohistochemical expression, genomic copy number and hotspot mutation status in neuroblastomas.

Platform comparison for evaluation of ALK protein immunohistochemical expression, genomic copy number and hotspot mutation status in neuroblastomas.

ALK is an established causative oncogenic driver in neuroblastoma, and is likely to emerge as a routine biomarker in neuroblastoma diagnostics. At present, the optimal strategy for clinical diagnostic evaluation of ALK protein, genomic and hotspot mutation status is not well-studied. We evaluated AL...

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Main Authors: Benedict Yan, Chik Hong Kuick, Malcolm Lim, Kavita Venkataraman, Chandana Tennakoon, Eva Loh, Derrick Lian, May Ying Leong, Manikandan Lakshmanan, Vinay Tergaonkar, Wing-Kin Sung, Shui Yen Soh, Kenneth T E Chang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4154751?pdf=render

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