Tamarind xyloglucan attenuates dextran sodium sulfate induced ulcerative colitis: Role of antioxidation
Ulcerative colitis (UC) is the leading chronic gastrointestinal disorder, if untreated can cause colon cancer. We characterized tamarind xyloglucan (TXG) as an edible nano-fiber and investigated its role in UC mice. TXG was an efficient free radical quencher and antioxidant in nature. TXG increased...
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doaj-6588879341b44f33bb92f3aa9d8cfc432021-04-30T07:12:53ZengElsevierJournal of Functional Foods1756-46462018-03-0142327338Tamarind xyloglucan attenuates dextran sodium sulfate induced ulcerative colitis: Role of antioxidationSrinivasan Periasamy0Chia-Hui Lin1Balaji Nagarajan2Nehru Viji Sankaranarayanan3Umesh R. Desai4Ming-Yie Liu5Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 70428, TaiwanDepartment of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 70428, TaiwanInstitute for Structural Biology, Drug Discovery and Development and Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA, United StatesInstitute for Structural Biology, Drug Discovery and Development and Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA, United StatesInstitute for Structural Biology, Drug Discovery and Development and Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA, United StatesDepartment of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan; Corresponding author at: Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70428, Taiwan.Ulcerative colitis (UC) is the leading chronic gastrointestinal disorder, if untreated can cause colon cancer. We characterized tamarind xyloglucan (TXG) as an edible nano-fiber and investigated its role in UC mice. TXG was an efficient free radical quencher and antioxidant in nature. TXG increased the cell viability in DSS-induced cytotoxicity of intestinal epithelial cells (IEC-6) and quenched intracellular reactive oxygen species in IEC-6 cells. Experimental colitis was induced in C57BL/6 mice by administering DSS 3% (w/v) in drinking water; TXG 100 and 300 mg/kg/day were given orally for 7 days simultaneously. TXG protected the colon by attenuating inflammatory cell infiltration, submucosal edema and crypt abscesses. TXG decreased oxidative stress by decreasing MDA, superoxide anion count, iNOS, NOX, COX-2 and p47 expression. Additionally, TXG decreased inflammation by decreasing TNF-α and increasing IL-10. Altogether, TXG is a novel antioxidant and plays an important role in attenuating DSS-induced UC in mice.http://www.sciencedirect.com/science/article/pii/S1756464618300203Tamarind xyloglucanUlcerative colitisOxidative stressAntioxidantMucosal protectionDietary fiber |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Srinivasan Periasamy Chia-Hui Lin Balaji Nagarajan Nehru Viji Sankaranarayanan Umesh R. Desai Ming-Yie Liu |
spellingShingle |
Srinivasan Periasamy Chia-Hui Lin Balaji Nagarajan Nehru Viji Sankaranarayanan Umesh R. Desai Ming-Yie Liu Tamarind xyloglucan attenuates dextran sodium sulfate induced ulcerative colitis: Role of antioxidation Journal of Functional Foods Tamarind xyloglucan Ulcerative colitis Oxidative stress Antioxidant Mucosal protection Dietary fiber |
author_facet |
Srinivasan Periasamy Chia-Hui Lin Balaji Nagarajan Nehru Viji Sankaranarayanan Umesh R. Desai Ming-Yie Liu |
author_sort |
Srinivasan Periasamy |
title |
Tamarind xyloglucan attenuates dextran sodium sulfate induced ulcerative colitis: Role of antioxidation |
title_short |
Tamarind xyloglucan attenuates dextran sodium sulfate induced ulcerative colitis: Role of antioxidation |
title_full |
Tamarind xyloglucan attenuates dextran sodium sulfate induced ulcerative colitis: Role of antioxidation |
title_fullStr |
Tamarind xyloglucan attenuates dextran sodium sulfate induced ulcerative colitis: Role of antioxidation |
title_full_unstemmed |
Tamarind xyloglucan attenuates dextran sodium sulfate induced ulcerative colitis: Role of antioxidation |
title_sort |
tamarind xyloglucan attenuates dextran sodium sulfate induced ulcerative colitis: role of antioxidation |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2018-03-01 |
description |
Ulcerative colitis (UC) is the leading chronic gastrointestinal disorder, if untreated can cause colon cancer. We characterized tamarind xyloglucan (TXG) as an edible nano-fiber and investigated its role in UC mice. TXG was an efficient free radical quencher and antioxidant in nature. TXG increased the cell viability in DSS-induced cytotoxicity of intestinal epithelial cells (IEC-6) and quenched intracellular reactive oxygen species in IEC-6 cells. Experimental colitis was induced in C57BL/6 mice by administering DSS 3% (w/v) in drinking water; TXG 100 and 300 mg/kg/day were given orally for 7 days simultaneously. TXG protected the colon by attenuating inflammatory cell infiltration, submucosal edema and crypt abscesses. TXG decreased oxidative stress by decreasing MDA, superoxide anion count, iNOS, NOX, COX-2 and p47 expression. Additionally, TXG decreased inflammation by decreasing TNF-α and increasing IL-10. Altogether, TXG is a novel antioxidant and plays an important role in attenuating DSS-induced UC in mice. |
topic |
Tamarind xyloglucan Ulcerative colitis Oxidative stress Antioxidant Mucosal protection Dietary fiber |
url |
http://www.sciencedirect.com/science/article/pii/S1756464618300203 |
work_keys_str_mv |
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