Osteocalcin expression of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) added with hydroxyapatite (HA) in rabbit’s post extraction tooth sockets
Introduction: Platelets play an important role in wound healing because it is a reservoir for growth factors and cytokines which is important in bone regeneration and soft tissue healing. The purpose of this study was to compare the use of scaffolds in platelet-rich fibrin (PRF) and platelet-rich pl...
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doaj-659290554abd47edb2f9b307b036bd172021-06-02T07:09:07ZengUniversitas PadjadjaranPadjadjaran Journal of Dentistry1979-02012549-62122020-11-0132324324810.24198/pjd.vol32no3.2484813813Osteocalcin expression of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) added with hydroxyapatite (HA) in rabbit’s post extraction tooth socketsMeta Maulida Damayanti0Bethy Suryawathy Hernowo1Susi Susanah2Universitas PadjadjaranUniversitas PadjadjaranHasan Sadikin HospitalIntroduction: Platelets play an important role in wound healing because it is a reservoir for growth factors and cytokines which is important in bone regeneration and soft tissue healing. The purpose of this study was to compare the use of scaffolds in platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) which added with hydroxyapatite (HA) in the socket healing process after tooth extraction in the value of regenerating an alveolar bone tissue. Methods: The research was conducted at biomedical laboratory Bandung Islamic University. Eighteen rabbits (Oryctolagus cuniculus) with extracted anterior and inferior teeth were divided into 2 treatment groups and 3 observation times. The tooth socket is filled with PRF (Group 1) and PRP + HA (Group 2). The observation was conducted on Day 3, Day 7 and Day 14. Immunoexpression Osteocalcin was performed to assess the healing process of alveolar bone. Data was analyzed with the SPSS software program. Analysis of normality data by Shapiro-Wilk test, homogeneity of variance with Levene's test and comparison between treatment groups with the Chi-square test. Results: Group 1 shown the average score was higher than in Group 2 with a strong category of 72.2% for Group 1 and 56.6% for Group 2. Based on statistically, there was no difference in osteocalcin immunoexpression between Group 1 and Group 2 with the p-value>0.05. Conclusion: Regeneration of rabbit’s alveolar bone tissue by application of PRF and PRP plus HA as scaffolds have results was similar. The use of PRF in post-extraction wound recovery is a better choice because it has an easy procedure and lower cost.http://jurnal.unpad.ac.id/pjd/article/view/24848hydroxyapatite (ha)osteocalcin expressionplatelet-rich fibrin (prf)platelet-rich plasma (prp)tooth socket |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meta Maulida Damayanti Bethy Suryawathy Hernowo Susi Susanah |
spellingShingle |
Meta Maulida Damayanti Bethy Suryawathy Hernowo Susi Susanah Osteocalcin expression of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) added with hydroxyapatite (HA) in rabbit’s post extraction tooth sockets Padjadjaran Journal of Dentistry hydroxyapatite (ha) osteocalcin expression platelet-rich fibrin (prf) platelet-rich plasma (prp) tooth socket |
author_facet |
Meta Maulida Damayanti Bethy Suryawathy Hernowo Susi Susanah |
author_sort |
Meta Maulida Damayanti |
title |
Osteocalcin expression of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) added with hydroxyapatite (HA) in rabbit’s post extraction tooth sockets |
title_short |
Osteocalcin expression of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) added with hydroxyapatite (HA) in rabbit’s post extraction tooth sockets |
title_full |
Osteocalcin expression of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) added with hydroxyapatite (HA) in rabbit’s post extraction tooth sockets |
title_fullStr |
Osteocalcin expression of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) added with hydroxyapatite (HA) in rabbit’s post extraction tooth sockets |
title_full_unstemmed |
Osteocalcin expression of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) added with hydroxyapatite (HA) in rabbit’s post extraction tooth sockets |
title_sort |
osteocalcin expression of platelet-rich fibrin (prf) and platelet-rich plasma (prp) added with hydroxyapatite (ha) in rabbit’s post extraction tooth sockets |
publisher |
Universitas Padjadjaran |
series |
Padjadjaran Journal of Dentistry |
issn |
1979-0201 2549-6212 |
publishDate |
2020-11-01 |
description |
Introduction: Platelets play an important role in wound healing because it is a reservoir for growth factors and cytokines which is important in bone regeneration and soft tissue healing. The purpose of this study was to compare the use of scaffolds in platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) which added with hydroxyapatite (HA) in the socket healing process after tooth extraction in the value of regenerating an alveolar bone tissue. Methods: The research was conducted at biomedical laboratory Bandung Islamic University. Eighteen rabbits (Oryctolagus cuniculus) with extracted anterior and inferior teeth were divided into 2 treatment groups and 3 observation times. The tooth socket is filled with PRF (Group 1) and PRP + HA (Group 2). The observation was conducted on Day 3, Day 7 and Day 14. Immunoexpression Osteocalcin was performed to assess the healing process of alveolar bone. Data was analyzed with the SPSS software program. Analysis of normality data by Shapiro-Wilk test, homogeneity of variance with Levene's test and comparison between treatment groups with the Chi-square test. Results: Group 1 shown the average score was higher than in Group 2 with a strong category of 72.2% for Group 1 and 56.6% for Group 2. Based on statistically, there was no difference in osteocalcin immunoexpression between Group 1 and Group 2 with the p-value>0.05. Conclusion: Regeneration of rabbit’s alveolar bone tissue by application of PRF and PRP plus HA as scaffolds have results was similar. The use of PRF in post-extraction wound recovery is a better choice because it has an easy procedure and lower cost. |
topic |
hydroxyapatite (ha) osteocalcin expression platelet-rich fibrin (prf) platelet-rich plasma (prp) tooth socket |
url |
http://jurnal.unpad.ac.id/pjd/article/view/24848 |
work_keys_str_mv |
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