Immunity to TBEV Related Flaviviruses with Reduced Pathogenicity Protects Mice from Disease but Not from TBEV Entry into the CNS

Immunity to TBEV Related Flaviviruses with Reduced Pathogenicity Protects Mice from Disease but Not from TBEV Entry into the CNS

Tick-borne encephalitis virus (TBEV) is a leading cause of vector-borne viral encephalitis with expanding endemic regions across Europe. In this study we tested in mice the efficacy of preinfection with a closely related low-virulent flavivirus, Langat virus (LGTV strain TP21), or a naturally avirul...

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Bibliographic Details
Main Authors: Monique Petry, Martin Palus, Eva Leitzen, Johanna Gracia Mitterreiter, Bei Huang, Andrea Kröger, Georges M. G. M. Verjans, Wolfgang Baumgärtner, Guus F. Rimmelzwaan, Daniel Růžek, Albert Osterhaus, Chittappen Kandiyil Prajeeth
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Vaccines
Subjects:
tick-borne encephalitis virus
Langat virus
CNS
neuronal damage
virus induced immunity
Online Access:https://www.mdpi.com/2076-393X/9/3/196

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