Correlates of non-typhoidal Salmonella bacteraemia: A case–control study
Objective: Limited up-to-date evidence exists on host-related characteristics of non-typhoidal Salmonella (NTS) bacteraemia in high-income countries. Correlates of NTS bacteraemia in Israel were examined in this study. Methods: A case–control study was conducted using the medical records of patients...
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doaj-65a59283572b45fe9e6bc76b5e180f362020-11-25T01:02:46ZengElsevierInternational Journal of Infectious Diseases1201-97122019-04-0181170175Correlates of non-typhoidal Salmonella bacteraemia: A case–control studyDavid Katz0Eli Ben-Chetrit1Shay-Shmuel Sherer2Daniel Cohen3Khitam Muhsen4Medical Department D, Shaare Zedek Medical Centre, affiliated with the Hebrew University School of Medicine, Jerusalem, IsraelInfectious Diseases Unit, Shaare Zedek Medical Centre, affiliated with the Hebrew University School of Medicine, Jerusalem, IsraelDepartment of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Corresponding author at: Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.Objective: Limited up-to-date evidence exists on host-related characteristics of non-typhoidal Salmonella (NTS) bacteraemia in high-income countries. Correlates of NTS bacteraemia in Israel were examined in this study. Methods: A case–control study was conducted using the medical records of patients hospitalized with NTS bacteraemia in Jerusalem during 1997–2016 (n = 106; 57 children, 49 adults). Two control groups were included: (1) randomly selected controls (n = 101), who were patients hospitalized due to bacteraemia with other pathogens; (2) patients with salmonellosis without bacteraemia (n = 112). Age-stratified logistic regression models were constructed. Results: In children, a recent emergency room visit was associated with an increased likelihood of NTS bacteraemia. In adults, the likelihood of NTS bacteraemia versus salmonellosis increased in relation to Charlson comorbidity score (adjusted odds ratio (aOR) 1.29, 95% confidence interval (CI) 1.00–1.66, for each 1-point increase in the score), while an inverse association was found with haemoglobin level (aOR 0.72, 95% CI 0.54–0.95). Steroid therapy increased the likelihood of NTS bacteraemia compared to patients with bacteraemia due to other pathogens (aOR 5.22, 95% CI 1.01–26.93). Conclusions: In children, NTS bacteraemia was probably present at their prior emergency room visit. A high comorbidity burden increased the likelihood of bacteraemia in adults with Salmonella infection, while haemoglobin level might be protective. Keywords: Non-typhoidal Salmonella, Bacteraemia, High-income country, Case–control, Hospitalizations, Immunosuppressionhttp://www.sciencedirect.com/science/article/pii/S1201971219300396 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
David Katz Eli Ben-Chetrit Shay-Shmuel Sherer Daniel Cohen Khitam Muhsen |
spellingShingle |
David Katz Eli Ben-Chetrit Shay-Shmuel Sherer Daniel Cohen Khitam Muhsen Correlates of non-typhoidal Salmonella bacteraemia: A case–control study International Journal of Infectious Diseases |
author_facet |
David Katz Eli Ben-Chetrit Shay-Shmuel Sherer Daniel Cohen Khitam Muhsen |
author_sort |
David Katz |
title |
Correlates of non-typhoidal Salmonella bacteraemia: A case–control study |
title_short |
Correlates of non-typhoidal Salmonella bacteraemia: A case–control study |
title_full |
Correlates of non-typhoidal Salmonella bacteraemia: A case–control study |
title_fullStr |
Correlates of non-typhoidal Salmonella bacteraemia: A case–control study |
title_full_unstemmed |
Correlates of non-typhoidal Salmonella bacteraemia: A case–control study |
title_sort |
correlates of non-typhoidal salmonella bacteraemia: a case–control study |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 |
publishDate |
2019-04-01 |
description |
Objective: Limited up-to-date evidence exists on host-related characteristics of non-typhoidal Salmonella (NTS) bacteraemia in high-income countries. Correlates of NTS bacteraemia in Israel were examined in this study. Methods: A case–control study was conducted using the medical records of patients hospitalized with NTS bacteraemia in Jerusalem during 1997–2016 (n = 106; 57 children, 49 adults). Two control groups were included: (1) randomly selected controls (n = 101), who were patients hospitalized due to bacteraemia with other pathogens; (2) patients with salmonellosis without bacteraemia (n = 112). Age-stratified logistic regression models were constructed. Results: In children, a recent emergency room visit was associated with an increased likelihood of NTS bacteraemia. In adults, the likelihood of NTS bacteraemia versus salmonellosis increased in relation to Charlson comorbidity score (adjusted odds ratio (aOR) 1.29, 95% confidence interval (CI) 1.00–1.66, for each 1-point increase in the score), while an inverse association was found with haemoglobin level (aOR 0.72, 95% CI 0.54–0.95). Steroid therapy increased the likelihood of NTS bacteraemia compared to patients with bacteraemia due to other pathogens (aOR 5.22, 95% CI 1.01–26.93). Conclusions: In children, NTS bacteraemia was probably present at their prior emergency room visit. A high comorbidity burden increased the likelihood of bacteraemia in adults with Salmonella infection, while haemoglobin level might be protective. Keywords: Non-typhoidal Salmonella, Bacteraemia, High-income country, Case–control, Hospitalizations, Immunosuppression |
url |
http://www.sciencedirect.com/science/article/pii/S1201971219300396 |
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