Ovarian tissue grafting: Lessons learnt from our experience with 55 grafts
Abstract Purpose Uncertainties remain regarding the clinical efficacy of ovarian tissue cryopreservation and grafting. We report a retrospective analysis of reproductive outcomes and lessons learnt following 55 ovarian tissue transplant procedures at our center from 2006 to 2019. Methods We analyzed...
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Online Access: | https://doi.org/10.1002/rmb2.12380 |
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doaj-65b98d5171394a17a218348b4fb8a5ce2021-07-03T10:30:55ZengWileyReproductive Medicine and Biology1445-57811447-05782021-07-0120327728810.1002/rmb2.12380Ovarian tissue grafting: Lessons learnt from our experience with 55 graftsGenia Rozen0Stephanie Avagliano1Franca Agresta2Debra Gook3Alex Polyakov4Catharyn Stern5Reproductive Services Unit Royal Women's Hospital Parkville, Melbourne Vic. AustraliaReproductive Services Unit Royal Women's Hospital Parkville, Melbourne Vic. AustraliaReproductive Services Unit Royal Women's Hospital Parkville, Melbourne Vic. AustraliaReproductive Services Unit Royal Women's Hospital Parkville, Melbourne Vic. AustraliaReproductive Services Unit Royal Women's Hospital Parkville, Melbourne Vic. AustraliaReproductive Services Unit Royal Women's Hospital Parkville, Melbourne Vic. AustraliaAbstract Purpose Uncertainties remain regarding the clinical efficacy of ovarian tissue cryopreservation and grafting. We report a retrospective analysis of reproductive outcomes and lessons learnt following 55 ovarian tissue transplant procedures at our center from 2006 to 2019. Methods We analyzed variables related to graft success such as tissue volume, follicular density, total follicular volume, and age on the duration of graft function. Results Follicular density and total follicular volume correlate positively with duration of graft function. All clinical pregnancies in our cohort occurred in women who were aged 35 or less at the time of ovarian tissue cryopreservation. Conclusion Graft success, as determined by eventual pregnancy and the longevity of graft function, may be impacted by factors including age at cryopreservation, follicular density, and total follicular volume.https://doi.org/10.1002/rmb2.12380assisted reproductive technologycryopreservation of germ cellsendocrinologyfertility of femaleoncology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Genia Rozen Stephanie Avagliano Franca Agresta Debra Gook Alex Polyakov Catharyn Stern |
spellingShingle |
Genia Rozen Stephanie Avagliano Franca Agresta Debra Gook Alex Polyakov Catharyn Stern Ovarian tissue grafting: Lessons learnt from our experience with 55 grafts Reproductive Medicine and Biology assisted reproductive technology cryopreservation of germ cells endocrinology fertility of female oncology |
author_facet |
Genia Rozen Stephanie Avagliano Franca Agresta Debra Gook Alex Polyakov Catharyn Stern |
author_sort |
Genia Rozen |
title |
Ovarian tissue grafting: Lessons learnt from our experience with 55 grafts |
title_short |
Ovarian tissue grafting: Lessons learnt from our experience with 55 grafts |
title_full |
Ovarian tissue grafting: Lessons learnt from our experience with 55 grafts |
title_fullStr |
Ovarian tissue grafting: Lessons learnt from our experience with 55 grafts |
title_full_unstemmed |
Ovarian tissue grafting: Lessons learnt from our experience with 55 grafts |
title_sort |
ovarian tissue grafting: lessons learnt from our experience with 55 grafts |
publisher |
Wiley |
series |
Reproductive Medicine and Biology |
issn |
1445-5781 1447-0578 |
publishDate |
2021-07-01 |
description |
Abstract Purpose Uncertainties remain regarding the clinical efficacy of ovarian tissue cryopreservation and grafting. We report a retrospective analysis of reproductive outcomes and lessons learnt following 55 ovarian tissue transplant procedures at our center from 2006 to 2019. Methods We analyzed variables related to graft success such as tissue volume, follicular density, total follicular volume, and age on the duration of graft function. Results Follicular density and total follicular volume correlate positively with duration of graft function. All clinical pregnancies in our cohort occurred in women who were aged 35 or less at the time of ovarian tissue cryopreservation. Conclusion Graft success, as determined by eventual pregnancy and the longevity of graft function, may be impacted by factors including age at cryopreservation, follicular density, and total follicular volume. |
topic |
assisted reproductive technology cryopreservation of germ cells endocrinology fertility of female oncology |
url |
https://doi.org/10.1002/rmb2.12380 |
work_keys_str_mv |
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1721321064992079872 |