From Yeast to Mammals, the Nonsense-Mediated mRNA Decay as a Master Regulator of Long Non-Coding RNAs Functional Trajectory

From Yeast to Mammals, the Nonsense-Mediated mRNA Decay as a Master Regulator of Long Non-Coding RNAs Functional Trajectory

The Nonsense-Mediated mRNA Decay (NMD) has been classically viewed as a translation-dependent RNA surveillance pathway degrading aberrant mRNAs containing premature stop codons. However, it is now clear that mRNA quality control represents only one face of the multiple functions of NMD. Indeed, NMD...

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Main Authors: Sara Andjus, Antonin Morillon, Maxime Wery
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Non-Coding RNA
Subjects:
nonsense-mediated mRNA decay
Upf1
lncRNA
translation
micropeptide
Online Access:https://www.mdpi.com/2311-553X/7/3/44
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spelling doaj-65bdb09fbb4a40ebaf3381049ef31ebd2021-09-26T00:49:49ZengMDPI AGNon-Coding RNA2311-553X2021-07-017444410.3390/ncrna7030044From Yeast to Mammals, the Nonsense-Mediated mRNA Decay as a Master Regulator of Long Non-Coding RNAs Functional TrajectorySara Andjus0Antonin Morillon1Maxime Wery2ncRNA, Epigenetic and Genome Fluidity, Institut Curie, PSL University, Sorbonne Université, CNRS UMR3244, 26 Rue d’Ulm, CEDEX 05, F-75248 Paris, FrancencRNA, Epigenetic and Genome Fluidity, Institut Curie, Sorbonne Université, CNRS UMR3244, 26 Rue d’Ulm, CEDEX 05, F-75248 Paris, FrancencRNA, Epigenetic and Genome Fluidity, Institut Curie, Sorbonne Université, CNRS UMR3244, 26 Rue d’Ulm, CEDEX 05, F-75248 Paris, FranceThe Nonsense-Mediated mRNA Decay (NMD) has been classically viewed as a translation-dependent RNA surveillance pathway degrading aberrant mRNAs containing premature stop codons. However, it is now clear that mRNA quality control represents only one face of the multiple functions of NMD. Indeed, NMD also regulates the physiological expression of normal mRNAs, and more surprisingly, of long non-coding (lnc)RNAs. Here, we review the different mechanisms of NMD activation in yeast and mammals, and we discuss the molecular bases of the NMD sensitivity of lncRNAs, considering the functional roles of NMD and of translation in the metabolism of these transcripts. In this regard, we describe several examples of functional micropeptides produced from lncRNAs. We propose that translation and NMD provide potent means to regulate the expression of lncRNAs, which might be critical for the cell to respond to environmental changes.https://www.mdpi.com/2311-553X/7/3/44nonsense-mediated mRNA decayUpf1lncRNAtranslationmicropeptide
collection DOAJ
language English
format Article
sources DOAJ
author Sara Andjus
Antonin Morillon
Maxime Wery
spellingShingle Sara Andjus
Antonin Morillon
Maxime Wery
From Yeast to Mammals, the Nonsense-Mediated mRNA Decay as a Master Regulator of Long Non-Coding RNAs Functional Trajectory
Non-Coding RNA
nonsense-mediated mRNA decay
Upf1
lncRNA
translation
micropeptide
author_facet Sara Andjus
Antonin Morillon
Maxime Wery
author_sort Sara Andjus
title From Yeast to Mammals, the Nonsense-Mediated mRNA Decay as a Master Regulator of Long Non-Coding RNAs Functional Trajectory
title_short From Yeast to Mammals, the Nonsense-Mediated mRNA Decay as a Master Regulator of Long Non-Coding RNAs Functional Trajectory
title_full From Yeast to Mammals, the Nonsense-Mediated mRNA Decay as a Master Regulator of Long Non-Coding RNAs Functional Trajectory
title_fullStr From Yeast to Mammals, the Nonsense-Mediated mRNA Decay as a Master Regulator of Long Non-Coding RNAs Functional Trajectory
title_full_unstemmed From Yeast to Mammals, the Nonsense-Mediated mRNA Decay as a Master Regulator of Long Non-Coding RNAs Functional Trajectory
title_sort from yeast to mammals, the nonsense-mediated mrna decay as a master regulator of long non-coding rnas functional trajectory
publisher MDPI AG
series Non-Coding RNA
issn 2311-553X
publishDate 2021-07-01
description The Nonsense-Mediated mRNA Decay (NMD) has been classically viewed as a translation-dependent RNA surveillance pathway degrading aberrant mRNAs containing premature stop codons. However, it is now clear that mRNA quality control represents only one face of the multiple functions of NMD. Indeed, NMD also regulates the physiological expression of normal mRNAs, and more surprisingly, of long non-coding (lnc)RNAs. Here, we review the different mechanisms of NMD activation in yeast and mammals, and we discuss the molecular bases of the NMD sensitivity of lncRNAs, considering the functional roles of NMD and of translation in the metabolism of these transcripts. In this regard, we describe several examples of functional micropeptides produced from lncRNAs. We propose that translation and NMD provide potent means to regulate the expression of lncRNAs, which might be critical for the cell to respond to environmental changes.
topic nonsense-mediated mRNA decay
Upf1
lncRNA
translation
micropeptide
url https://www.mdpi.com/2311-553X/7/3/44
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