TRANSVERSE MYELITIS IN A MYASTHENIA GRAVIS PATIENT. A CASE PRESENTATION
Myasthenia gravis (MG) is an autoimmune disease caused by the presence of immunoglobulin G (IgG)1 and IgG3 complement activating antibodies against the nicotinic acetylcholine receptor, which affects the neuromuscular junction leading to fluctuating muscle weakness due to impaired neuromuscular tran...
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doaj-65ec024bac264dfdba840c1c207c727b2020-11-25T01:50:54ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942016-03-01151444710.37897/RJN.2016.1.7TRANSVERSE MYELITIS IN A MYASTHENIA GRAVIS PATIENT. A CASE PRESENTATIONRuxanda Dana Chirileanu0Mihaela Simu1Cecilia Rosca2Raluca Tudor3Patricia Jurca4“Victor Babes” University of Medicine and Pharmacy, Timisoara; Department of Neurology, Emergency County Hospital of Timisoara“Victor Babes” University of Medicine and Pharmacy, Timisoara; Department of Neurology, Emergency County Hospital of Timisoara“Victor Babes” University of Medicine and Pharmacy, Timisoara; Department of Neurology, Emergency County Hospital of Timisoara“Victor Babes” University of Medicine and Pharmacy, Timisoara; Department of Neurology, Emergency County Hospital of TimisoaraDepartment of Neurology, Emergency County Hospital of TimisoaraMyasthenia gravis (MG) is an autoimmune disease caused by the presence of immunoglobulin G (IgG)1 and IgG3 complement activating antibodies against the nicotinic acetylcholine receptor, which affects the neuromuscular junction leading to fluctuating muscle weakness due to impaired neuromuscular transmition. The association of MG and demyelinating diseases is rare, but it has been described before and it could be part of an unspecifi c immune activation, due to genetic susceptibility or it could just happen randomly. Demyelinating diseases (DD) in MG patients can occur as monophasic events (myelitis, optic neuritis, acute disseminated encephalomyelitis) or recurrent diseases (multiple sclerosis, recurrent transverse myelitis) and since the incidence of DD is higher in MG patients than in general population this association could be part of an autoimune syndrome or genetically induced. We present the case of a 30 year old woman who presented with an unspecific onset of MG and after 5 months was readmitted to our unit with transverse myelitis (with negative aquaporin 4 antibodies) which regressed after 5 days of combined intravenous corticotherapy and immunoglobulin treatment. https://revistemedicale.amaltea.ro/Romanian_Journal_of_NEUROLOGY/Revista_Romana_de_NEUROLOGIE-2016-Nr.1/RJN_2016_1_Art-07.pdfmyastenia gravistransverse myelitisaquaporin 4 antibodiesautoimune syndrome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ruxanda Dana Chirileanu Mihaela Simu Cecilia Rosca Raluca Tudor Patricia Jurca |
spellingShingle |
Ruxanda Dana Chirileanu Mihaela Simu Cecilia Rosca Raluca Tudor Patricia Jurca TRANSVERSE MYELITIS IN A MYASTHENIA GRAVIS PATIENT. A CASE PRESENTATION Romanian Journal of Neurology myastenia gravis transverse myelitis aquaporin 4 antibodies autoimune syndrome |
author_facet |
Ruxanda Dana Chirileanu Mihaela Simu Cecilia Rosca Raluca Tudor Patricia Jurca |
author_sort |
Ruxanda Dana Chirileanu |
title |
TRANSVERSE MYELITIS IN A MYASTHENIA GRAVIS PATIENT. A CASE PRESENTATION |
title_short |
TRANSVERSE MYELITIS IN A MYASTHENIA GRAVIS PATIENT. A CASE PRESENTATION |
title_full |
TRANSVERSE MYELITIS IN A MYASTHENIA GRAVIS PATIENT. A CASE PRESENTATION |
title_fullStr |
TRANSVERSE MYELITIS IN A MYASTHENIA GRAVIS PATIENT. A CASE PRESENTATION |
title_full_unstemmed |
TRANSVERSE MYELITIS IN A MYASTHENIA GRAVIS PATIENT. A CASE PRESENTATION |
title_sort |
transverse myelitis in a myasthenia gravis patient. a case presentation |
publisher |
Amaltea Medical Publishing House |
series |
Romanian Journal of Neurology |
issn |
1843-8148 2069-6094 |
publishDate |
2016-03-01 |
description |
Myasthenia gravis (MG) is an autoimmune disease caused by the presence of immunoglobulin G (IgG)1 and IgG3 complement activating antibodies against the nicotinic acetylcholine receptor, which affects the neuromuscular junction leading to fluctuating muscle weakness due to impaired neuromuscular transmition. The association of MG and demyelinating diseases is rare, but it has been described before and it could be part of an unspecifi c immune activation, due to genetic susceptibility or it could just happen randomly. Demyelinating diseases (DD) in MG
patients can occur as monophasic events (myelitis, optic neuritis, acute disseminated encephalomyelitis) or recurrent diseases (multiple sclerosis, recurrent transverse myelitis) and since the incidence of DD is higher in MG patients than in general population this association could be part of an autoimune syndrome or genetically induced. We present the case of a 30 year old woman who presented with an unspecific onset of MG and after 5 months was readmitted to our unit with transverse myelitis (with negative aquaporin 4 antibodies) which regressed after 5 days of combined intravenous corticotherapy and immunoglobulin treatment. |
topic |
myastenia gravis transverse myelitis aquaporin 4 antibodies autoimune syndrome |
url |
https://revistemedicale.amaltea.ro/Romanian_Journal_of_NEUROLOGY/Revista_Romana_de_NEUROLOGIE-2016-Nr.1/RJN_2016_1_Art-07.pdf |
work_keys_str_mv |
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