Aporphine alkaloids with antitubercular activity isolated from Ocotea discolor Kunth (Lauraceae)
Tuberculosis disease causes thousands of deaths worldwide and, currently, the used drugs are either not enough or obsolete for its treatment. Therefore, new compounds that combat this disease are been seek. Thus, the antituberculosis activity of the alkaloids ocoxilonine (1), ocoteine (2), dicentrin...
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Universidad Nacional de Colombia
2017-09-01
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doaj-65f79d1f32a146b6b41330972d3a4d5b2020-11-24T20:51:24ZengUniversidad Nacional de ColombiaRevista Colombiana de Química0120-28042357-37912017-09-01463222710.15446/rev.colomb.quim.v46n3.6296345440Aporphine alkaloids with antitubercular activity isolated from Ocotea discolor Kunth (Lauraceae)Monica Constanza Avila Murillo0Lady Tatiana Albarracin Melo1Luis Enrique Cuca Suárez2Oscar Javier Patiño Ladino3Juan David Guzman Vasquez4Thimothy Mchugh5Neelu Begum6Laboratorio de Investigación en Productos Naturales Vegetales, Departamento de Química, Facultad de Ciencias, Universidad Nacional de ColombiaLaboratorio de Investigación en Productos Naturales Vegetales, Departamento de Química, Facultad de Ciencias, Universidad Nacional de ColombiaLaboratorio de Investigación en Productos Naturales Vegetales, Departamento de Química, Facultad de Ciencias, Universidad Nacional de ColombiaLaboratorio de Investigación en Productos Naturales Vegetales, Departamento de Química, Facultad de Ciencias, Universidad Nacional de ColombiaUniversidad del NorteUniversity Collegue LondonUniversity Collegue LondonTuberculosis disease causes thousands of deaths worldwide and, currently, the used drugs are either not enough or obsolete for its treatment. Therefore, new compounds that combat this disease are been seek. Thus, the antituberculosis activity of the alkaloids ocoxilonine (1), ocoteine (2), dicentrine (3) and 1,2-methylenedioxy-3,10,11-trimethoxyaporphine (4), isolated from Ocotea discolor wood was evaluated. Their structures were identified by analysis of nuclear magnetic resonance spectroscopic data (NMR 1D – 1H, 13C, 2D – COSY, HSQC and HMBC), mass spectra, and comparison with literature data. All the isolated compounds demonstrated antituberculosis activity, with ocoteine (2) being the most active compound, with a minimum inhibitory concentration value of 140 μM against the virulent strain Mycobacterium tuberculosis H37Rv. All the isolated compounds showed antituberculosis activity, with a variation range in the minimum inhibitory concentration between 140 to 310 μM, being ocoteine (2) the most active compound against the virulent strain Mycobacterium tuberculosis H37Rv.https://revistas.unal.edu.co/index.php/rcolquim/article/view/62963Mycobacterium tuberculosisdatos espectroscópicosOcoteina |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Monica Constanza Avila Murillo Lady Tatiana Albarracin Melo Luis Enrique Cuca Suárez Oscar Javier Patiño Ladino Juan David Guzman Vasquez Thimothy Mchugh Neelu Begum |
spellingShingle |
Monica Constanza Avila Murillo Lady Tatiana Albarracin Melo Luis Enrique Cuca Suárez Oscar Javier Patiño Ladino Juan David Guzman Vasquez Thimothy Mchugh Neelu Begum Aporphine alkaloids with antitubercular activity isolated from Ocotea discolor Kunth (Lauraceae) Revista Colombiana de Química Mycobacterium tuberculosis datos espectroscópicos Ocoteina |
author_facet |
Monica Constanza Avila Murillo Lady Tatiana Albarracin Melo Luis Enrique Cuca Suárez Oscar Javier Patiño Ladino Juan David Guzman Vasquez Thimothy Mchugh Neelu Begum |
author_sort |
Monica Constanza Avila Murillo |
title |
Aporphine alkaloids with antitubercular activity isolated from Ocotea discolor Kunth (Lauraceae) |
title_short |
Aporphine alkaloids with antitubercular activity isolated from Ocotea discolor Kunth (Lauraceae) |
title_full |
Aporphine alkaloids with antitubercular activity isolated from Ocotea discolor Kunth (Lauraceae) |
title_fullStr |
Aporphine alkaloids with antitubercular activity isolated from Ocotea discolor Kunth (Lauraceae) |
title_full_unstemmed |
Aporphine alkaloids with antitubercular activity isolated from Ocotea discolor Kunth (Lauraceae) |
title_sort |
aporphine alkaloids with antitubercular activity isolated from ocotea discolor kunth (lauraceae) |
publisher |
Universidad Nacional de Colombia |
series |
Revista Colombiana de Química |
issn |
0120-2804 2357-3791 |
publishDate |
2017-09-01 |
description |
Tuberculosis disease causes thousands of deaths worldwide and, currently, the used drugs are either not enough or obsolete for its treatment. Therefore, new compounds that combat this disease are been seek. Thus, the antituberculosis activity of the alkaloids ocoxilonine (1), ocoteine (2), dicentrine (3) and 1,2-methylenedioxy-3,10,11-trimethoxyaporphine (4), isolated from Ocotea discolor wood was evaluated. Their structures were identified by analysis of nuclear magnetic resonance spectroscopic data (NMR 1D – 1H, 13C, 2D – COSY, HSQC and HMBC), mass spectra, and comparison with literature data. All the isolated compounds demonstrated antituberculosis activity, with ocoteine (2) being the most active compound, with a minimum inhibitory concentration value of 140 μM against the virulent strain Mycobacterium tuberculosis H37Rv. All the isolated compounds showed antituberculosis activity, with a variation range in the minimum inhibitory concentration between 140 to 310 μM, being ocoteine (2) the most active compound against the virulent strain Mycobacterium tuberculosis H37Rv. |
topic |
Mycobacterium tuberculosis datos espectroscópicos Ocoteina |
url |
https://revistas.unal.edu.co/index.php/rcolquim/article/view/62963 |
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