The Impact of the Nitric Oxide (NO)/Soluble Guanylyl Cyclase (sGC) Signaling Cascade on Kidney Health and Disease: A Preclinical Perspective

The Impact of the Nitric Oxide (NO)/Soluble Guanylyl Cyclase (sGC) Signaling Cascade on Kidney Health and Disease: A Preclinical Perspective

Chronic Kidney Disease (CKD) is a highly prevalent disease with a substantial medical need for new and more efficacious treatments. The Nitric Oxide (NO), soluble guanylyl cyclase (sGC), cyclic guanosine monophosphate (cGMP) signaling cascade regulates various kidney functions. cGMP directly influen...

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Bibliographic Details
Main Authors: Shalini M. Krishnan, Jan R. Kraehling, Frank Eitner, Agnès Bénardeau, Peter Sandner
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:International Journal of Molecular Sciences
Subjects:
nitric oxide
cGMP
chronic kidney disease
soluble guanylyl cyclase
sGC
sGC stimulator
sGC activator
Online Access:http://www.mdpi.com/1422-0067/19/6/1712

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