Silencing of Hypoglossal Motoneurons Leads to Sleep Disordered Breathing in Lean Mice

Silencing of Hypoglossal Motoneurons Leads to Sleep Disordered Breathing in Lean Mice

Obstructive Sleep Apnea (OSA) is a prevalent condition and a major cause of morbidity and mortality in Western Society. The loss of motor input to the tongue and specifically to the genioglossus muscle during sleep is associated with pharyngeal collapsibility and the development of OSA. We applied a...

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Bibliographic Details
Main Authors: Thomaz A. Fleury Curado, Huy Pho, Olga Dergacheva, Slava Berger, Rachel Lee, Carla Freire, Aya Asherov, Luis U. Sennes, David Mendelowitz, Alan R. Schwartz, Vsevolod Y. Polotsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Neurology
Subjects:
obstructive sleeep apnea
chemogenetic
sleep
upper airway
neuromuscular activity
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00962/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2018.00962/full

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