Influence of Chronic Periodontitis on the Long-Term Mortality and Cardiovascular Events in Kidney Transplant Recipients
Chronic periodontitis (CP) is associated with cardiovascular disease and mortality in different populations. The aim of this study was to examine an association of CP with hard endpoints in patients after kidney transplantation during a 15-year follow-up period. Study group consist of 117 patients (...
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doaj-661e6984eec2424791c67755fae3ac712020-11-25T02:31:22ZengMDPI AGJournal of Clinical Medicine2077-03832020-06-0191968196810.3390/jcm9061968Influence of Chronic Periodontitis on the Long-Term Mortality and Cardiovascular Events in Kidney Transplant RecipientsMarta Wynimko0Magdalena Walicka1Yaroslav Sanchak2Dariusz Gozdowski3Anna Błach4Andrzej Więcek5Andrzej Śliwczyński6Edward Franek7Aureliusz Kolonko8Department of Internal Diseases, Endocrinology and Diabetology, Central Clinical Hospital MSWiA, Wołoska 137, 02-507 Warsaw, PolandDepartment of Internal Diseases, Endocrinology and Diabetology, Central Clinical Hospital MSWiA, Wołoska 137, 02-507 Warsaw, PolandDepartment of Internal Diseases, Endocrinology and Diabetology, Central Clinical Hospital MSWiA, Wołoska 137, 02-507 Warsaw, PolandDepartment of Biometry, Warsaw University of Life Sciences, Nowoursynowska 166, 02-787 Warsaw, PolandDepartment of Cardiology, Medical University of Silesia, Francuska 20, 40-027 Katowice, PolandDepartment of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20, 40-027 Katowice, PolandUniversity of Humanities and Economics in Lodz, Sattelite Campus, Wolność 2a, 01-018 Warsaw, PolandDepartment of Internal Diseases, Endocrinology and Diabetology, Central Clinical Hospital MSWiA, Wołoska 137, 02-507 Warsaw, PolandDepartment of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20, 40-027 Katowice, PolandChronic periodontitis (CP) is associated with cardiovascular disease and mortality in different populations. The aim of this study was to examine an association of CP with hard endpoints in patients after kidney transplantation during a 15-year follow-up period. Study group consist of 117 patients (77M/40F, median age 44 years) divided into two subgroups: those with initially advanced CP (CPITN 3–4) and those with no or moderate CP (CPITN 0–2). All cardiovascular events, graft losses, and re-transplantations were recorded. All deaths were noted and verified, including those occurred after the return to dialysis therapy, the causes of death were identified. Cox regression with Firth’s penalized maximum likelihood models were used for data analysis. During the observation period, 49 deaths occurred. Advanced CP (<i>n </i>= 35) was not associated with overall mortality but was associated with increased risk of death with functioning graft (DWFG) [HR 3.54 (1.20–10.45); <i>p</i> < 0.05]. Risk of graft loss was not associated with CP status. In conclusion, an advanced CP was independently associated with increased risk of DWFG, but not all-cause or cardiovascular mortality after renal transplantation.https://www.mdpi.com/2077-0383/9/6/1968kidney transplantationperiodontal diseasesurvivalmortalitydeathcardiovascular complications |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marta Wynimko Magdalena Walicka Yaroslav Sanchak Dariusz Gozdowski Anna Błach Andrzej Więcek Andrzej Śliwczyński Edward Franek Aureliusz Kolonko |
spellingShingle |
Marta Wynimko Magdalena Walicka Yaroslav Sanchak Dariusz Gozdowski Anna Błach Andrzej Więcek Andrzej Śliwczyński Edward Franek Aureliusz Kolonko Influence of Chronic Periodontitis on the Long-Term Mortality and Cardiovascular Events in Kidney Transplant Recipients Journal of Clinical Medicine kidney transplantation periodontal disease survival mortality death cardiovascular complications |
author_facet |
Marta Wynimko Magdalena Walicka Yaroslav Sanchak Dariusz Gozdowski Anna Błach Andrzej Więcek Andrzej Śliwczyński Edward Franek Aureliusz Kolonko |
author_sort |
Marta Wynimko |
title |
Influence of Chronic Periodontitis on the Long-Term Mortality and Cardiovascular Events in Kidney Transplant Recipients |
title_short |
Influence of Chronic Periodontitis on the Long-Term Mortality and Cardiovascular Events in Kidney Transplant Recipients |
title_full |
Influence of Chronic Periodontitis on the Long-Term Mortality and Cardiovascular Events in Kidney Transplant Recipients |
title_fullStr |
Influence of Chronic Periodontitis on the Long-Term Mortality and Cardiovascular Events in Kidney Transplant Recipients |
title_full_unstemmed |
Influence of Chronic Periodontitis on the Long-Term Mortality and Cardiovascular Events in Kidney Transplant Recipients |
title_sort |
influence of chronic periodontitis on the long-term mortality and cardiovascular events in kidney transplant recipients |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-06-01 |
description |
Chronic periodontitis (CP) is associated with cardiovascular disease and mortality in different populations. The aim of this study was to examine an association of CP with hard endpoints in patients after kidney transplantation during a 15-year follow-up period. Study group consist of 117 patients (77M/40F, median age 44 years) divided into two subgroups: those with initially advanced CP (CPITN 3–4) and those with no or moderate CP (CPITN 0–2). All cardiovascular events, graft losses, and re-transplantations were recorded. All deaths were noted and verified, including those occurred after the return to dialysis therapy, the causes of death were identified. Cox regression with Firth’s penalized maximum likelihood models were used for data analysis. During the observation period, 49 deaths occurred. Advanced CP (<i>n </i>= 35) was not associated with overall mortality but was associated with increased risk of death with functioning graft (DWFG) [HR 3.54 (1.20–10.45); <i>p</i> < 0.05]. Risk of graft loss was not associated with CP status. In conclusion, an advanced CP was independently associated with increased risk of DWFG, but not all-cause or cardiovascular mortality after renal transplantation. |
topic |
kidney transplantation periodontal disease survival mortality death cardiovascular complications |
url |
https://www.mdpi.com/2077-0383/9/6/1968 |
work_keys_str_mv |
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