Current Molecular Markers of Melanoma and Treatment Targets
Melanoma is a deadly skin cancer that becomes especially difficult to treat after it metastasizes. Timely identification of melanoma is critical for effective therapy, but histopathologic diagnosis can frequently pose a significant challenge to this goal. Therefore, auxiliary diagnostic tools are im...
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doaj-6625a1a988ce4ea988f15282f990ece62020-11-25T02:59:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-01213535353510.3390/ijms21103535Current Molecular Markers of Melanoma and Treatment TargetsKevin Yang0Allen S.W. Oak1Radomir M. Slominski2Anna A. Brożyna3Andrzej T. Slominski4Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USADivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Human Biology, Institute of Biology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, 87-100 Toruń, PolandDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USAMelanoma is a deadly skin cancer that becomes especially difficult to treat after it metastasizes. Timely identification of melanoma is critical for effective therapy, but histopathologic diagnosis can frequently pose a significant challenge to this goal. Therefore, auxiliary diagnostic tools are imperative to facilitating prompt recognition of malignant lesions. Melanoma develops as result of a number of genetic mutations, with UV radiation often acting as a mutagenic risk factor. Novel methods of genetic testing have improved detection of these molecular alterations, which subsequently revealed important information for diagnosis and prognosis. Rapid detection of genetic alterations is also significant for choosing appropriate treatment and developing targeted therapies for melanoma. This review will delve into the understanding of various mutations and the implications they may pose for clinical decision making.https://www.mdpi.com/1422-0067/21/10/3535melanomamolecular pathologydiagnosistherapymolecular testinggenetic mutations |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kevin Yang Allen S.W. Oak Radomir M. Slominski Anna A. Brożyna Andrzej T. Slominski |
spellingShingle |
Kevin Yang Allen S.W. Oak Radomir M. Slominski Anna A. Brożyna Andrzej T. Slominski Current Molecular Markers of Melanoma and Treatment Targets International Journal of Molecular Sciences melanoma molecular pathology diagnosis therapy molecular testing genetic mutations |
author_facet |
Kevin Yang Allen S.W. Oak Radomir M. Slominski Anna A. Brożyna Andrzej T. Slominski |
author_sort |
Kevin Yang |
title |
Current Molecular Markers of Melanoma and Treatment Targets |
title_short |
Current Molecular Markers of Melanoma and Treatment Targets |
title_full |
Current Molecular Markers of Melanoma and Treatment Targets |
title_fullStr |
Current Molecular Markers of Melanoma and Treatment Targets |
title_full_unstemmed |
Current Molecular Markers of Melanoma and Treatment Targets |
title_sort |
current molecular markers of melanoma and treatment targets |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-05-01 |
description |
Melanoma is a deadly skin cancer that becomes especially difficult to treat after it metastasizes. Timely identification of melanoma is critical for effective therapy, but histopathologic diagnosis can frequently pose a significant challenge to this goal. Therefore, auxiliary diagnostic tools are imperative to facilitating prompt recognition of malignant lesions. Melanoma develops as result of a number of genetic mutations, with UV radiation often acting as a mutagenic risk factor. Novel methods of genetic testing have improved detection of these molecular alterations, which subsequently revealed important information for diagnosis and prognosis. Rapid detection of genetic alterations is also significant for choosing appropriate treatment and developing targeted therapies for melanoma. This review will delve into the understanding of various mutations and the implications they may pose for clinical decision making. |
topic |
melanoma molecular pathology diagnosis therapy molecular testing genetic mutations |
url |
https://www.mdpi.com/1422-0067/21/10/3535 |
work_keys_str_mv |
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