Clinical observation of mitomycin and 5-fluorouracil with adjustable sutural trabeculectomy for glaucoma
AIM: To take a contrastive analysis of glaucoma patients' clinical prognosis and complications after the usage of mitomycin(MMC)or 5-fluorouracil(5-FU)combined with adjustable sutural trabeculectomy. <p>METHODS: Retrospective case series reseach was undertaken. We divided the 71 cases(inc...
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doaj-66301e1d33ff437a8d32969e3d8d46d82020-11-25T02:36:25ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232018-10-0118101906190810.3980/j.issn.1672-5123.2018.10.37Clinical observation of mitomycin and 5-fluorouracil with adjustable sutural trabeculectomy for glaucomaXiao-Li Chen0Li Bin1Zhi-Ke Xu2Department of Ophthalmology, People's Hospital of Leshan, Leshan 614000, Sichuan Province, ChinaDepartment of Ophthalmology, People's Hospital of Leshan, Leshan 614000, Sichuan Province, ChinaDepartment of Ophthalmology, People's Hospital of Leshan, Leshan 614000, Sichuan Province, ChinaAIM: To take a contrastive analysis of glaucoma patients' clinical prognosis and complications after the usage of mitomycin(MMC)or 5-fluorouracil(5-FU)combined with adjustable sutural trabeculectomy. <p>METHODS: Retrospective case series reseach was undertaken. We divided the 71 cases(including primary open angle glaucoma and primary chronic angle-closure glaucoma)into two groups: MMC group(36 cases)and 5-FU group(35 cases). Both were treated with combined adjustable sutural trabeculectomy with the usage of MMC or 5-FU anti-cicatricial treatment, and followed up to compare intraocular pressure, filtered bubble form and complications. <p>RESULTS: The intraocular pressure of MMC group was lower than 5-FU group with statistical significance(<i>P</i><0.05); there was no significant difference in total surgical success rate between groups(<i>P</i>>0.05). Functional filtering bleb formation rate in MMC group was higher than 5-FU group while the formation rate of nonfunctional filtering bleb in MMC group was lower than 5-FU group(<i>P</i><0.05), which showed no significant difference in complication rate between groups(<i>P</i>>0.05), but the types of complications were different. <p>CONCLUSION: Both MMC and 5-FU can improve the success rate of glaucoma trabeculectomy as anti-cicatricial drugs. MMC can lower the intraocular pressure, is superior to 5-FU in the formation of functional filtering bleb. There was no significant difference in the incidence of complications between MMC and 5-FU according to personalized surgical protocols based on patients. When 5-FU is used, it is necessary to separate the filtering blebs repeatedly after operation and to reinject 5-FU under conjunctiva.http://ies.ijo.cn/cn_publish/2018/10/201810037.pdfglaucomaadjustable suturetrabeculectomymytomycin C5-fluorouracilprognosisprognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiao-Li Chen Li Bin Zhi-Ke Xu |
spellingShingle |
Xiao-Li Chen Li Bin Zhi-Ke Xu Clinical observation of mitomycin and 5-fluorouracil with adjustable sutural trabeculectomy for glaucoma Guoji Yanke Zazhi glaucoma adjustable suture trabeculectomy mytomycin C 5-fluorouracil prognosis prognosis |
author_facet |
Xiao-Li Chen Li Bin Zhi-Ke Xu |
author_sort |
Xiao-Li Chen |
title |
Clinical observation of mitomycin and 5-fluorouracil with adjustable sutural trabeculectomy for glaucoma |
title_short |
Clinical observation of mitomycin and 5-fluorouracil with adjustable sutural trabeculectomy for glaucoma |
title_full |
Clinical observation of mitomycin and 5-fluorouracil with adjustable sutural trabeculectomy for glaucoma |
title_fullStr |
Clinical observation of mitomycin and 5-fluorouracil with adjustable sutural trabeculectomy for glaucoma |
title_full_unstemmed |
Clinical observation of mitomycin and 5-fluorouracil with adjustable sutural trabeculectomy for glaucoma |
title_sort |
clinical observation of mitomycin and 5-fluorouracil with adjustable sutural trabeculectomy for glaucoma |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
Guoji Yanke Zazhi |
issn |
1672-5123 1672-5123 |
publishDate |
2018-10-01 |
description |
AIM: To take a contrastive analysis of glaucoma patients' clinical prognosis and complications after the usage of mitomycin(MMC)or 5-fluorouracil(5-FU)combined with adjustable sutural trabeculectomy. <p>METHODS: Retrospective case series reseach was undertaken. We divided the 71 cases(including primary open angle glaucoma and primary chronic angle-closure glaucoma)into two groups: MMC group(36 cases)and 5-FU group(35 cases). Both were treated with combined adjustable sutural trabeculectomy with the usage of MMC or 5-FU anti-cicatricial treatment, and followed up to compare intraocular pressure, filtered bubble form and complications. <p>RESULTS: The intraocular pressure of MMC group was lower than 5-FU group with statistical significance(<i>P</i><0.05); there was no significant difference in total surgical success rate between groups(<i>P</i>>0.05). Functional filtering bleb formation rate in MMC group was higher than 5-FU group while the formation rate of nonfunctional filtering bleb in MMC group was lower than 5-FU group(<i>P</i><0.05), which showed no significant difference in complication rate between groups(<i>P</i>>0.05), but the types of complications were different. <p>CONCLUSION: Both MMC and 5-FU can improve the success rate of glaucoma trabeculectomy as anti-cicatricial drugs. MMC can lower the intraocular pressure, is superior to 5-FU in the formation of functional filtering bleb. There was no significant difference in the incidence of complications between MMC and 5-FU according to personalized surgical protocols based on patients. When 5-FU is used, it is necessary to separate the filtering blebs repeatedly after operation and to reinject 5-FU under conjunctiva. |
topic |
glaucoma adjustable suture trabeculectomy mytomycin C 5-fluorouracil prognosis prognosis |
url |
http://ies.ijo.cn/cn_publish/2018/10/201810037.pdf |
work_keys_str_mv |
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