Pro-inflammatory cytokines and depression in myocardial infarction

• Main Authors: O. L. Barbarash, N. B. Lebedeva, V. N. Karetnikova, S. A. Berns, V. V. Kashtalap, L. S. Barbarash
• Format: Article
• Language: Russian
• Published: «SILICEA-POLIGRAF» LLC 2011-04-01
• Series: Кардиоваскулярная терапия и профилактика
• Subjects: myocardial infarction; depression; anxiety; pro-inflammatory cytokines; prognosis
• Online Access: https://cardiovascular.elpub.ru/jour/article/view/1608

Aim. To assess the associations between inflammatory factors and anxiety (A) and depression (D) levels in patients with myocardial infarction (MI). Material and methods. The study included 100 MI patients, hospitalised with a diagnosis of Q-wave MI (mean age 62,0±1,3 years). The methods of psychosocial status assessment included Zung depression scale and SpielbergerKhanin personal and reactive anxiety scales. The inflammatory markers of interest included interleukins (IL) 1-beta, IL-6, IL-8, IL-10, and C-reactive protein (CRP). Results. D and A symptoms in the early post-MI stage were associated with higher risk of cardiovascular events in the following year. Among MI patients with comparable MI severity, D and A symptoms were linked to higher levels of pro-inflammatory cytokines IL-1-beta, IL-8, IL-8, and INF-gamma. Conclusion. In MI patients with D and A symptoms, one of the mechanisms of poor prognosis is an activation of subclinical inflammation.