Sinonasal lymphomas in Indonesia: immunophenotype and Epstein-Barr virus association
Sinonasal lymphoma is a rare disease with NK/T-cell (NKTC) or B-cell immunophenotype. Previous study revealed the geographic difference in frequency of NKTC lymphoma (NKTCL) and almost constant association with Epstein-Barr virus (EBV) infection. Through review of 41 cases with sinonasal lymphoprol...
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Faculty of Medicine Universitas Indonesia
2004-05-01
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doaj-663425dd87ce4ba19ca42c096286334d2020-11-25T01:30:49ZengFaculty of Medicine Universitas Indonesia Medical Journal of Indonesia0853-17732252-80832004-05-0113210.13181/mji.v13i2.133133Sinonasal lymphomas in Indonesia: immunophenotype and Epstein-Barr virus associationEndang S.R. HardjolukitoAntonius N. KurniawanRia KodariahMaria F. HamWen-Juan LuoShin-Ichi NakatsukaKatsuyuki Aozasa Sinonasal lymphoma is a rare disease with NK/T-cell (NKTC) or B-cell immunophenotype. Previous study revealed the geographic difference in frequency of NKTC lymphoma (NKTCL) and almost constant association with Epstein-Barr virus (EBV) infection. Through review of 41 cases with sinonasal lymphoproliferative diseases registered in the Department of Anatomical Pathology, University of Indonesia during the period 1994 to 2002, thirty-five were accepted as sinonasal lymphoma. Immunohistochemistry revealed that 20 cases (57%) were NK/T-cell type and 15 (43%) B-cell type with large cell morphology, i.e.,diffuse large B-cell lymphoma. NKTCL showed a marked male preponderance (M/F= 4:1) and younger onset of disease (median age, 37 years), and B-cell lymphoma showed a relative female preponderance (1:1.5) and older disease onset (median age, 49 years). In situ hybridization using EBER-1 probe revealed that 90% of NKTCL were EBV-positive, but none of B-cell lymphoma were EBV-positive. This is the first report on sinonasal lymphoma in Indonesia showing relative predominance of B-cell lymphoma compared to other Asian countries and Peru (14-24%). Lack of EBV-association in Indonesian sinonasal B-cell lymphoma showed a marked contrast to that in other Asian countries (EBV positive rate, 25-41 %). Predominance of sinonasal B-cell lymphoma without EBV genome might suggest presence of specific etiologic factors in Indonesia. (Med J Indones 2004; 13: 71-6) Keywords: sinonasal lymphoma, B-cell, NK/T-cell, Epstein-Barr virus, Indonesia http://mji.ui.ac.id/journal/index.php/mji/article/view/133 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Endang S.R. Hardjolukito Antonius N. Kurniawan Ria Kodariah Maria F. Ham Wen-Juan Luo Shin-Ichi Nakatsuka Katsuyuki Aozasa |
spellingShingle |
Endang S.R. Hardjolukito Antonius N. Kurniawan Ria Kodariah Maria F. Ham Wen-Juan Luo Shin-Ichi Nakatsuka Katsuyuki Aozasa Sinonasal lymphomas in Indonesia: immunophenotype and Epstein-Barr virus association Medical Journal of Indonesia |
author_facet |
Endang S.R. Hardjolukito Antonius N. Kurniawan Ria Kodariah Maria F. Ham Wen-Juan Luo Shin-Ichi Nakatsuka Katsuyuki Aozasa |
author_sort |
Endang S.R. Hardjolukito |
title |
Sinonasal lymphomas in Indonesia: immunophenotype and Epstein-Barr virus association |
title_short |
Sinonasal lymphomas in Indonesia: immunophenotype and Epstein-Barr virus association |
title_full |
Sinonasal lymphomas in Indonesia: immunophenotype and Epstein-Barr virus association |
title_fullStr |
Sinonasal lymphomas in Indonesia: immunophenotype and Epstein-Barr virus association |
title_full_unstemmed |
Sinonasal lymphomas in Indonesia: immunophenotype and Epstein-Barr virus association |
title_sort |
sinonasal lymphomas in indonesia: immunophenotype and epstein-barr virus association |
publisher |
Faculty of Medicine Universitas Indonesia |
series |
Medical Journal of Indonesia |
issn |
0853-1773 2252-8083 |
publishDate |
2004-05-01 |
description |
Sinonasal lymphoma is a rare disease with NK/T-cell (NKTC) or B-cell immunophenotype. Previous study revealed the geographic difference in frequency of NKTC lymphoma (NKTCL) and almost constant association with Epstein-Barr virus (EBV) infection. Through review of 41 cases with sinonasal lymphoproliferative diseases registered in the Department of Anatomical Pathology, University of Indonesia during the period 1994 to 2002, thirty-five were accepted as sinonasal lymphoma. Immunohistochemistry revealed that 20 cases (57%) were NK/T-cell type and 15 (43%) B-cell type with large cell morphology, i.e.,diffuse large B-cell lymphoma. NKTCL showed a marked male preponderance (M/F= 4:1) and younger onset of disease (median age, 37 years), and B-cell lymphoma showed a relative female preponderance (1:1.5) and older disease onset (median age, 49 years). In situ hybridization using EBER-1 probe revealed that 90% of NKTCL were EBV-positive, but none of B-cell lymphoma were EBV-positive. This is the first report on sinonasal lymphoma in Indonesia showing relative predominance of B-cell lymphoma compared to other Asian countries and Peru (14-24%). Lack of EBV-association in Indonesian sinonasal B-cell lymphoma showed a marked contrast to that in other Asian countries (EBV positive rate, 25-41 %). Predominance of sinonasal B-cell lymphoma without EBV genome might suggest presence of specific etiologic factors in Indonesia. (Med J Indones 2004; 13: 71-6)
Keywords: sinonasal lymphoma, B-cell, NK/T-cell, Epstein-Barr virus, Indonesia
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url |
http://mji.ui.ac.id/journal/index.php/mji/article/view/133 |
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