Interactions of the α3β2 Nicotinic Acetylcholine Receptor Interfaces with α-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations
Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders. The (α3)<sub>2</sub>(β2)<sub>3</sub> nAChR subunit arrangemen...
Main Authors: | Jierong Wen, David J. Adams, Andrew Hung |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-07-01
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Series: | Marine Drugs |
Subjects: | |
Online Access: | https://www.mdpi.com/1660-3397/18/7/349 |
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