The role of the odorant receptors in the formation of the sensory map

The role of the odorant receptors in the formation of the sensory map

Abstract In the olfactory system, odorant receptors (ORs) expressed at the cell membrane of olfactory sensory neurons detect odorants and direct sensory axons toward precise target locations in the brain, reflected in the presence of olfactory sensory maps. This dual role of ORs is corroborated by t...

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Main Authors: Simona Francia, Claudia Lodovichi
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Biology
Online Access:https://doi.org/10.1186/s12915-021-01116-y
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spelling doaj-66495d112df94063a2eae9273b35bffd2021-08-29T11:45:59ZengBMCBMC Biology1741-70072021-08-0119111810.1186/s12915-021-01116-yThe role of the odorant receptors in the formation of the sensory mapSimona Francia0Claudia Lodovichi1Center for Synaptic Neuroscience and Technology, Istituto Italiano di TecnologiaVeneto Institute of Molecular MedicineAbstract In the olfactory system, odorant receptors (ORs) expressed at the cell membrane of olfactory sensory neurons detect odorants and direct sensory axons toward precise target locations in the brain, reflected in the presence of olfactory sensory maps. This dual role of ORs is corroborated by their subcellular expression both in cilia, where they bind odorants, and at axon terminals, a location suitable for axon guidance cues. Here, we provide an overview and discuss previous work on the role of ORs in establishing the topographic organization of the olfactory system and recent findings on the mechanisms of activation and function of axonal ORs.https://doi.org/10.1186/s12915-021-01116-y
collection DOAJ
language English
format Article
sources DOAJ
author Simona Francia
Claudia Lodovichi
spellingShingle Simona Francia
Claudia Lodovichi
The role of the odorant receptors in the formation of the sensory map
BMC Biology
author_facet Simona Francia
Claudia Lodovichi
author_sort Simona Francia
title The role of the odorant receptors in the formation of the sensory map
title_short The role of the odorant receptors in the formation of the sensory map
title_full The role of the odorant receptors in the formation of the sensory map
title_fullStr The role of the odorant receptors in the formation of the sensory map
title_full_unstemmed The role of the odorant receptors in the formation of the sensory map
title_sort role of the odorant receptors in the formation of the sensory map
publisher BMC
series BMC Biology
issn 1741-7007
publishDate 2021-08-01
description Abstract In the olfactory system, odorant receptors (ORs) expressed at the cell membrane of olfactory sensory neurons detect odorants and direct sensory axons toward precise target locations in the brain, reflected in the presence of olfactory sensory maps. This dual role of ORs is corroborated by their subcellular expression both in cilia, where they bind odorants, and at axon terminals, a location suitable for axon guidance cues. Here, we provide an overview and discuss previous work on the role of ORs in establishing the topographic organization of the olfactory system and recent findings on the mechanisms of activation and function of axonal ORs.
url https://doi.org/10.1186/s12915-021-01116-y
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