An economic evaluation of antihypertensive therapies based on clinical trials
OBJECTIVE: Hypertension is a major issue in public health, and the financial costs associated with hypertension continue to increase. Cost-effectiveness studies focusing on antihypertensive drug combinations, however, have been scarce. The cost-effectiveness ratios of the traditional treatment (hydr...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Faculdade de Medicina / USP
2012-01-01
|
Series: | Clinics |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000100007 |
id |
doaj-664ae46f2c694835b7219e9629bb9f9a |
---|---|
record_format |
Article |
spelling |
doaj-664ae46f2c694835b7219e9629bb9f9a2020-11-24T23:34:42ZengFaculdade de Medicina / USPClinics1807-59321980-53222012-01-01671414810.6061/clinics/2012(01)07An economic evaluation of antihypertensive therapies based on clinical trialsRosana Lima Garcia TsujiGiovanio Vieira da SilvaKatia Coelho OrtegaOtavio BerwangerDecio Mion JúniorOBJECTIVE: Hypertension is a major issue in public health, and the financial costs associated with hypertension continue to increase. Cost-effectiveness studies focusing on antihypertensive drug combinations, however, have been scarce. The cost-effectiveness ratios of the traditional treatment (hydrochlorothiazide and atenolol) and the current treatment (losartan and amlodipine) were evaluated in patients with grade 1 or 2 hypertension (HT1-2). For patients with grade 3 hypertension (HT3), a third drug was added to the treatment combinations: enalapril was added to the traditional treatment, and hydrochlorothiazide was added to the current treatment. METHODS: Hypertension treatment costs were estimated on the basis of the purchase prices of the antihypertensive medications, and effectiveness was measured as the reduction in systolic blood pressure and diastolic blood pressure (in mm Hg) at the end of a 12-month study period. RESULTS: When the purchase price of the brand-name medication was used to calculate the cost, the traditional treatment presented a lower cost-effectiveness ratio [US$/mm Hg] than the current treatment in the HT1-2 group. In the HT3 group, however, there was no difference in cost-effectiveness ratio between the traditional treatment and the current treatment. The cost-effectiveness ratio differences between the treatment regimens maintained the same pattern when the purchase price of the lower-cost medication was used. CONCLUSIONS: We conclude that the traditional treatment is more cost-effective (US$/mm Hg) than the current treatment in the HT1-2 group. There was no difference in cost-effectiveness between the traditional treatment and the current treatment for the HT3 group.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000100007HypertensionPharmacoeconomicsCost-effectivenessAntihypertensive drugs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rosana Lima Garcia Tsuji Giovanio Vieira da Silva Katia Coelho Ortega Otavio Berwanger Decio Mion Júnior |
spellingShingle |
Rosana Lima Garcia Tsuji Giovanio Vieira da Silva Katia Coelho Ortega Otavio Berwanger Decio Mion Júnior An economic evaluation of antihypertensive therapies based on clinical trials Clinics Hypertension Pharmacoeconomics Cost-effectiveness Antihypertensive drugs |
author_facet |
Rosana Lima Garcia Tsuji Giovanio Vieira da Silva Katia Coelho Ortega Otavio Berwanger Decio Mion Júnior |
author_sort |
Rosana Lima Garcia Tsuji |
title |
An economic evaluation of antihypertensive therapies based on clinical trials |
title_short |
An economic evaluation of antihypertensive therapies based on clinical trials |
title_full |
An economic evaluation of antihypertensive therapies based on clinical trials |
title_fullStr |
An economic evaluation of antihypertensive therapies based on clinical trials |
title_full_unstemmed |
An economic evaluation of antihypertensive therapies based on clinical trials |
title_sort |
economic evaluation of antihypertensive therapies based on clinical trials |
publisher |
Faculdade de Medicina / USP |
series |
Clinics |
issn |
1807-5932 1980-5322 |
publishDate |
2012-01-01 |
description |
OBJECTIVE: Hypertension is a major issue in public health, and the financial costs associated with hypertension continue to increase. Cost-effectiveness studies focusing on antihypertensive drug combinations, however, have been scarce. The cost-effectiveness ratios of the traditional treatment (hydrochlorothiazide and atenolol) and the current treatment (losartan and amlodipine) were evaluated in patients with grade 1 or 2 hypertension (HT1-2). For patients with grade 3 hypertension (HT3), a third drug was added to the treatment combinations: enalapril was added to the traditional treatment, and hydrochlorothiazide was added to the current treatment. METHODS: Hypertension treatment costs were estimated on the basis of the purchase prices of the antihypertensive medications, and effectiveness was measured as the reduction in systolic blood pressure and diastolic blood pressure (in mm Hg) at the end of a 12-month study period. RESULTS: When the purchase price of the brand-name medication was used to calculate the cost, the traditional treatment presented a lower cost-effectiveness ratio [US$/mm Hg] than the current treatment in the HT1-2 group. In the HT3 group, however, there was no difference in cost-effectiveness ratio between the traditional treatment and the current treatment. The cost-effectiveness ratio differences between the treatment regimens maintained the same pattern when the purchase price of the lower-cost medication was used. CONCLUSIONS: We conclude that the traditional treatment is more cost-effective (US$/mm Hg) than the current treatment in the HT1-2 group. There was no difference in cost-effectiveness between the traditional treatment and the current treatment for the HT3 group. |
topic |
Hypertension Pharmacoeconomics Cost-effectiveness Antihypertensive drugs |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000100007 |
work_keys_str_mv |
AT rosanalimagarciatsuji aneconomicevaluationofantihypertensivetherapiesbasedonclinicaltrials AT giovaniovieiradasilva aneconomicevaluationofantihypertensivetherapiesbasedonclinicaltrials AT katiacoelhoortega aneconomicevaluationofantihypertensivetherapiesbasedonclinicaltrials AT otavioberwanger aneconomicevaluationofantihypertensivetherapiesbasedonclinicaltrials AT deciomionjunior aneconomicevaluationofantihypertensivetherapiesbasedonclinicaltrials AT rosanalimagarciatsuji economicevaluationofantihypertensivetherapiesbasedonclinicaltrials AT giovaniovieiradasilva economicevaluationofantihypertensivetherapiesbasedonclinicaltrials AT katiacoelhoortega economicevaluationofantihypertensivetherapiesbasedonclinicaltrials AT otavioberwanger economicevaluationofantihypertensivetherapiesbasedonclinicaltrials AT deciomionjunior economicevaluationofantihypertensivetherapiesbasedonclinicaltrials |
_version_ |
1725527956890058752 |