The Predictive Value of EGFR Status in Non-small Cell Lung Cancer Patients Treated with EGFR-TKIs
Epidermal growth factor receptor (EGFR) is a major molecular for target therapy. The epidermal growth factor receptor tyrosine kinase inhibitors (TKIs), gefitinib (Iressa) and erlotinib (Tarceva), are two prospective agents towards non-small cell lung cancer (NSCLC). Multi-center clinical studies sh...
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2010-04-01
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Online Access: | http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2010.04.20&path[]=1441 |
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doaj-66502fb9799748fcb9180ff9fad707ed2020-11-24T23:11:12ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872010-04-01134375379The Predictive Value of EGFR Status in Non-small Cell Lung Cancer Patients Treated with EGFR-TKIsJun CHENHongyu LIUYuli WANGEpidermal growth factor receptor (EGFR) is a major molecular for target therapy. The epidermal growth factor receptor tyrosine kinase inhibitors (TKIs), gefitinib (Iressa) and erlotinib (Tarceva), are two prospective agents towards non-small cell lung cancer (NSCLC). Multi-center clinical studies showed that there were obvious differences between individuals by the treatment of EGFR-TKIs. EGFR status is the major factor that influences the outcome for the treatment by TKI. Exon mutations and amplification of EGFR molecule are the critical factors that predict good response to TKIs. On the other hand, KRAS mutations indicate the resistant to the TKIs.http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2010.04.20&path[]=1441EGFR-TKIsErlotinibGefitinibPCRFISHIHC |
collection |
DOAJ |
language |
zho |
format |
Article |
sources |
DOAJ |
author |
Jun CHEN Hongyu LIU Yuli WANG |
spellingShingle |
Jun CHEN Hongyu LIU Yuli WANG The Predictive Value of EGFR Status in Non-small Cell Lung Cancer Patients Treated with EGFR-TKIs Chinese Journal of Lung Cancer EGFR-TKIs Erlotinib Gefitinib PCR FISH IHC |
author_facet |
Jun CHEN Hongyu LIU Yuli WANG |
author_sort |
Jun CHEN |
title |
The Predictive Value of EGFR Status in Non-small Cell Lung Cancer Patients Treated with EGFR-TKIs |
title_short |
The Predictive Value of EGFR Status in Non-small Cell Lung Cancer Patients Treated with EGFR-TKIs |
title_full |
The Predictive Value of EGFR Status in Non-small Cell Lung Cancer Patients Treated with EGFR-TKIs |
title_fullStr |
The Predictive Value of EGFR Status in Non-small Cell Lung Cancer Patients Treated with EGFR-TKIs |
title_full_unstemmed |
The Predictive Value of EGFR Status in Non-small Cell Lung Cancer Patients Treated with EGFR-TKIs |
title_sort |
predictive value of egfr status in non-small cell lung cancer patients treated with egfr-tkis |
publisher |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
series |
Chinese Journal of Lung Cancer |
issn |
1009-3419 1999-6187 |
publishDate |
2010-04-01 |
description |
Epidermal growth factor receptor (EGFR) is a major molecular for target therapy. The epidermal growth factor receptor tyrosine kinase inhibitors (TKIs), gefitinib (Iressa) and erlotinib (Tarceva), are two prospective agents towards non-small cell lung cancer (NSCLC). Multi-center clinical studies showed that there were obvious differences between individuals by the treatment of EGFR-TKIs. EGFR status is the major factor that influences the outcome for the treatment by TKI. Exon mutations and amplification of EGFR molecule are the critical factors that predict good response to TKIs. On the other hand, KRAS mutations indicate the resistant to the TKIs. |
topic |
EGFR-TKIs Erlotinib Gefitinib PCR FISH IHC |
url |
http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2010.04.20&path[]=1441 |
work_keys_str_mv |
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