Correlation of serum levels of HIF-1α and IL-19 with the disease progression of COPD: a retrospective study

• Main Authors: Rong B, Liu Y, Li M, Fu T, Gao W, Liu H
• Format: Article
• Language: English
• Published: Dove Medical Press 2018-11-01
• Series: International Journal of COPD
• Subjects: chronic obstructive pulmonary disease; COPD; hypoxia-inducible factor 1 alpha; interleukin-19
• Online Access: https://www.dovepress.com/correlation-of-serum-levels-of-hif-1alpha-and-il-19-with-the-disease-p-peer-reviewed-article-COPD

Biaoxue Rong,1 Yufang Liu,2 Min Li,3 Tian Fu,4 Wenlong Gao,5 Hua Liu6 1Department of Respiratory Medicine, First Affiliated Hospital, Xi’an Medical University, Xi’an, China; 2Comprehensive Medicine Department, Shenmu Hospital, Shenmu, China; 3Department of Respiratory Medicine, Shenmu Hospital, Shenmu, China; 4Department of Respiratory Medicine, Jining No 1 People’s Hospital, Jining, China; 5Institute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou, China; 6Department of Respiratory Medicine, Gansu Provincial Hospital, Lanzhou, China Background: The aim of this study was to disclose the correlation between the serum levels of hypoxia-inducible factor 1 alpha (HIF-1α) and IL-19 and stable COPD.Methods: The serum levels of HIF-1α and IL-19 were tested by ELISA. The relationships between their levels and clinical parameters of stable COPD patients were analyzed by linear regression methods.Results: Patients with stable COPD showed higher serum levels of HIF-1α and IL-19 compared with healthy control group (P<0.001), and serum levels of HIF-1α and IL-19 had a positive linear correlation (P<0.05). In stable COPD patients, increased serum levels of HIF-1α and IL-19 were positively correlated with the GOLD grading (P<0.005), modified British Medical Research Council (mMRC) score (P<0.05), and medical history (P<0.05) but negatively related to the pulmonary function (P<0.05). The serum level of HIF-1α (P<0.05) was affected by the patient’s FEV1/FVC value and COPD grading, and the serum level of IL-19 was associated with the mMRC scores and the serum level of HIF-1α (P<0.05).Conclusion: Increased serum levels of HIF-1α and IL-19 correlated with the disease progression of COPD, suggesting that they can be used as indicators to help us understand the COPD. Keywords: chronic obstructive pulmonary disease, COPD, hypoxia-inducible factor 1 alpha, interleukin-19, serum, pulmonary function