Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer

Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer

Abstract Background Emerging evidence suggests a potential relationship between gut microbiota and the host response to chemotherapeutic drugs including 5-fluorouracil (5-Fu). Fusobacterium nucleatum (Fn) has been linked to the initiation and progression of colorectal cancer (CRC). Unfortunately, li...

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Bibliographic Details
Main Authors: Sheng Zhang, Yongzhi Yang, Wenhao Weng, Bomin Guo, Guoxiang Cai, Yanlei Ma, Sanjun Cai
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Fusobacterium nucleatum
BIRC3
5-fluorouracil
Chemoresistance
Colorectal cancer
Online Access:http://link.springer.com/article/10.1186/s13046-018-0985-y

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