A case of probable Vogt–Koyanagi–Harada disease in a 3-year-old girl
Abstract Background Vogt–Koyanagi–Harada (VKH) disease is a T-cell-mediated autoimmune disorder characterized by bilateral granulomatous panuveitis with various systemic manifestations. Although VKH disease rarely occurs in the pediatric population, the clinical course tends to be aggressive, and th...
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doaj-666b8875efd44968894b1205be6b1ea12020-11-25T03:34:52ZengBMCBMC Ophthalmology1471-24152019-08-011911410.1186/s12886-019-1192-0A case of probable Vogt–Koyanagi–Harada disease in a 3-year-old girlAtsuko Katsuyama0Sentaro Kusuhara1Hiroyuki Awano2Hiroaki Nagase3Wataru Matsumiya4Makoto Nakamura5Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of MedicineDivision of Ophthalmology, Department of Surgery, Kobe University Graduate School of MedicineDepartment of Pediatrics, Kobe University Graduate School of medicineDepartment of Pediatrics, Kobe University Graduate School of medicineDivision of Ophthalmology, Department of Surgery, Kobe University Graduate School of MedicineDivision of Ophthalmology, Department of Surgery, Kobe University Graduate School of MedicineAbstract Background Vogt–Koyanagi–Harada (VKH) disease is a T-cell-mediated autoimmune disorder characterized by bilateral granulomatous panuveitis with various systemic manifestations. Although VKH disease rarely occurs in the pediatric population, the clinical course tends to be aggressive, and the visual prognosis is worse than that in adult patients due to severe ocular complications secondary to recurrent inflammation. Case presentation A 3-year-old girl with probable VKH was referred to Kobe University Hospital. She had severe bilateral panuveitis with posterior synechiae of the iris, marked optic disk swelling, and serous retinal detachment in both eyes, and her best corrected visual acuities (BCVAs) were 20/200 OD and 20/125 OS. A third course of therapy was administered because serous retinal detachment remained after two courses of therapy. She was treated with three courses of high-dose intravenous corticosteroid therapy, followed by slow tapering of oral corticosteroids. Her BCVAs recovered to 20/16 OU, and relapse of ocular inflammation and side effect of treatment were not observed during the 1.5-year follow-up period. Conclusions We experienced a pediatric patient with probable VKH disease who was treated with three courses of high-dose intravenous corticosteroid therapy. With the favorable clinical course in our patient, initial treatment with repeated high-dose intravenous corticosteroid therapy might be beneficial in pediatric VKH disease.http://link.springer.com/article/10.1186/s12886-019-1192-0Vogt–Koyanagi–Harada diseaseChildUveitisCorticosteroid therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Atsuko Katsuyama Sentaro Kusuhara Hiroyuki Awano Hiroaki Nagase Wataru Matsumiya Makoto Nakamura |
spellingShingle |
Atsuko Katsuyama Sentaro Kusuhara Hiroyuki Awano Hiroaki Nagase Wataru Matsumiya Makoto Nakamura A case of probable Vogt–Koyanagi–Harada disease in a 3-year-old girl BMC Ophthalmology Vogt–Koyanagi–Harada disease Child Uveitis Corticosteroid therapy |
author_facet |
Atsuko Katsuyama Sentaro Kusuhara Hiroyuki Awano Hiroaki Nagase Wataru Matsumiya Makoto Nakamura |
author_sort |
Atsuko Katsuyama |
title |
A case of probable Vogt–Koyanagi–Harada disease in a 3-year-old girl |
title_short |
A case of probable Vogt–Koyanagi–Harada disease in a 3-year-old girl |
title_full |
A case of probable Vogt–Koyanagi–Harada disease in a 3-year-old girl |
title_fullStr |
A case of probable Vogt–Koyanagi–Harada disease in a 3-year-old girl |
title_full_unstemmed |
A case of probable Vogt–Koyanagi–Harada disease in a 3-year-old girl |
title_sort |
case of probable vogt–koyanagi–harada disease in a 3-year-old girl |
publisher |
BMC |
series |
BMC Ophthalmology |
issn |
1471-2415 |
publishDate |
2019-08-01 |
description |
Abstract Background Vogt–Koyanagi–Harada (VKH) disease is a T-cell-mediated autoimmune disorder characterized by bilateral granulomatous panuveitis with various systemic manifestations. Although VKH disease rarely occurs in the pediatric population, the clinical course tends to be aggressive, and the visual prognosis is worse than that in adult patients due to severe ocular complications secondary to recurrent inflammation. Case presentation A 3-year-old girl with probable VKH was referred to Kobe University Hospital. She had severe bilateral panuveitis with posterior synechiae of the iris, marked optic disk swelling, and serous retinal detachment in both eyes, and her best corrected visual acuities (BCVAs) were 20/200 OD and 20/125 OS. A third course of therapy was administered because serous retinal detachment remained after two courses of therapy. She was treated with three courses of high-dose intravenous corticosteroid therapy, followed by slow tapering of oral corticosteroids. Her BCVAs recovered to 20/16 OU, and relapse of ocular inflammation and side effect of treatment were not observed during the 1.5-year follow-up period. Conclusions We experienced a pediatric patient with probable VKH disease who was treated with three courses of high-dose intravenous corticosteroid therapy. With the favorable clinical course in our patient, initial treatment with repeated high-dose intravenous corticosteroid therapy might be beneficial in pediatric VKH disease. |
topic |
Vogt–Koyanagi–Harada disease Child Uveitis Corticosteroid therapy |
url |
http://link.springer.com/article/10.1186/s12886-019-1192-0 |
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