Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys

Wittmann and colleagues show that not only single outcome events but also the global reward state (GRS) impact learning in macaques; low GRS drives explorative choices. Analyses of macaque BOLD signal reveals that GRS impacts activity in the anterior insula as well as the dorsal raphe nucleus.

Bibliographic Details
Main Authors:	Marco K. Wittmann, Elsa Fouragnan, Davide Folloni, Miriam C. Klein-Flügge, Bolton K. H. Chau, Mehdi Khamassi, Matthew F. S. Rushworth
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17343-w

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spelling	doaj-66773931085e4cab80d38c39a1ebff532021-08-01T11:39:40ZengNature Publishing GroupNature Communications2041-17232020-07-0111111710.1038/s41467-020-17343-wGlobal reward state affects learning and activity in raphe nucleus and anterior insula in monkeysMarco K. Wittmann0Elsa Fouragnan1Davide Folloni2Miriam C. Klein-Flügge3Bolton K. H. Chau4Mehdi Khamassi5Matthew F. S. Rushworth6Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of OxfordWellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of OxfordWellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of OxfordWellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of OxfordDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic UniversitySorbonne Université, CNRS, Institute of Intelligent Systems and RoboticsWellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of OxfordWittmann and colleagues show that not only single outcome events but also the global reward state (GRS) impact learning in macaques; low GRS drives explorative choices. Analyses of macaque BOLD signal reveals that GRS impacts activity in the anterior insula as well as the dorsal raphe nucleus.https://doi.org/10.1038/s41467-020-17343-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Marco K. Wittmann Elsa Fouragnan Davide Folloni Miriam C. Klein-Flügge Bolton K. H. Chau Mehdi Khamassi Matthew F. S. Rushworth
spellingShingle	Marco K. Wittmann Elsa Fouragnan Davide Folloni Miriam C. Klein-Flügge Bolton K. H. Chau Mehdi Khamassi Matthew F. S. Rushworth Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys Nature Communications
author_facet	Marco K. Wittmann Elsa Fouragnan Davide Folloni Miriam C. Klein-Flügge Bolton K. H. Chau Mehdi Khamassi Matthew F. S. Rushworth
author_sort	Marco K. Wittmann
title	Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys
title_short	Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys
title_full	Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys
title_fullStr	Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys
title_full_unstemmed	Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys
title_sort	global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-07-01
description	Wittmann and colleagues show that not only single outcome events but also the global reward state (GRS) impact learning in macaques; low GRS drives explorative choices. Analyses of macaque BOLD signal reveals that GRS impacts activity in the anterior insula as well as the dorsal raphe nucleus.
url	https://doi.org/10.1038/s41467-020-17343-w
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Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys

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